Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
isoniazid resistant mmaA3
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Mtub_mmaA3_INH | Card Database | 1 | - | Mycobacterium tuberculosis H37Rv | - | - | NC_000962.3 | NP_215157.1 |
| mmaA3 | Reslit | 1 | isoniazid | Mycobacterium tuberculosis | Europe|Asia|Central Asia|Germany | 2020 | NCBI:PRJNA610123|NZ_HG813240.1|NC_020089.1 | - |
Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.
Indels in Mycobacterium tuberculosis are significantly enriched in antibiotic resistance genes, contributing to the evolution of multidrug resistance in an outbreak. Specific genes like pncA, mmaA3, ethA, espK, and nudC were identified as being disrupted by indels, leading to resistance against pyrazinamide, isoniazid, and ethionamide.
No comments yet. Be the first to comment!