Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N444K | - | increases bedaquiline efflux | Mycobacterium tuberculosis, Mycobacterium marinum | bedaquiline | Reslit | Candidate |
| Q196M | - | increases bedaquiline efflux | Mycobacterium tuberculosis, Mycobacterium marinum | bedaquiline | Reslit | Candidate |
| Y331D | - | increases bedaquiline efflux | Mycobacterium tuberculosis, Mycobacterium marinum | bedaquiline | Reslit | Candidate |
| V193D | - | increases bedaquiline efflux | Mycobacterium tuberculosis, Mycobacterium marinum | bedaquiline | Reslit | Candidate |
| V902A | - | increases bedaquiline efflux | Mycobacterium tuberculosis, Mycobacterium marinum | bedaquiline | Reslit | Candidate |
| S602P | - | - | Mycobacterium tuberculosis | bedaquiline | Reslit | Candidate |
| M925V | - | - | Mycobacterium tuberculosis | bedaquiline | Reslit | Candidate |
| Y300* | - | - | Mycobacterium tuberculosis | bedaquiline|clofazimine | Reslit | Candidate |
| F696L | - | - | Mycobacterium tuberculosis | clofazimine | Reslit | Candidate |
Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India.
The study identified that the efflux pump genes mmpL5, Rv0194, and Rv1250 were upregulated in rifampicin-resistant Mycobacterium tuberculosis isolates, suggesting their potential role in mediating rifampicin resistance.
Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.
Mutations in the transcriptional repressor mmpR5 lead to upregulation of the efflux pump mmpL5, causing resistance to SIMBL and bedaquiline in Mycobacterium tuberculosis.
Nontuberculous Mycobacterial Resistance to Antibiotics and Disinfectants: Challenges Still Ahead.
The paper discusses various AMR mechanisms in non-tuberculous mycobacteria (NTM), focusing on resistance to antibiotics such as ethambutol, macrolides, rifampin, bedaquiline, and clofazimine. Key genes and mutations identified include embB, erm, rpoB, atpE, mmpT5, pepQ, mmpL5, rplC, 23S rRNA, 16S rRNA, gyrA, and gyrB.
MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus.
Interred mechanisms of resistance and host immune evasion revealed through network-connectivity analysis of M. tuberculosis complex graph pangenome.
The study identified paralogous duplications of mmpL5 associated with bedaquiline resistance and embR associated with ethambutol resistance in Mycobacterium tuberculosis complex isolates.
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
The study identifies MmpL5 mutations that increase bedaquiline efflux, suggesting potential resistance mechanisms beyond pump upregulation.
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