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Explore antimicrobial resistance genes from the literature

mphH

macrolide phosphotransferase (MPH)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mphH

Browse AMR rules for mphH

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Drug Classes: ERYTHROMYCIN, AZITHROMYCIN, TYLOSIN
Organisms: Brachybacterium faecium DSM 4810
Alleles: 2
Papers: 1
Databases: Card DatabaseReference Gene Catalog

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
mphH	Card Database	1	-	Brachybacterium faecium DSM 4810	-	-	CP001643.1	ACU86041.1
MphH	Card DatabaseReference Gene Catalog	2	ERYTHROMYCIN, AZITHROMYCIN +1	Brachybacterium faecium DSM 4810	-	2018	CP001643.1	ACU86041.1

Papers1

1

Gene Information

Gene Name: mphH
Allele: mphH
Encodes: macrolide phosphotransferase (MPH)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Brachybacterium faecium DSM 4810
Sequence Accession: CP001643.1
Protein Accession: ACU86041.1
Notes: ARO:3004539

2

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.

PMID 29317655 · 2018

Gene Information

Gene Name: mphH
Allele: MphH
Encodes: macrolide 2'-phosphotransferase MphH
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: ERYTHROMYCINAZITHROMYCINTYLOSIN
Organisms Tested In: • Brachybacterium faecium DSM 4810
Sequence Accession: CP001643.1
Protein Accession: ACU86041.1
Notes: ARO:3004539

3

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.

PMID 29317655 · 2018

Gene Information

Gene Name: mphH
Allele: MphH
Encodes: macrolide 2'-phosphotransferase MphH
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: ERYTHROMYCINAZITHROMYCINTYLOSIN
Organisms Tested In: • Brachybacterium faecium DSM 4810
Sequence Accession: CP001643.1
Protein Accession: ACU86041.1
Notes: ARO:3004539

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