Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
mitomycin-binding protein
Overview
Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system.
The study identifies mct and mrd as novel genes involved in mitomycin C resistance in Streptomyces lavendulae, functioning as a drug export system and a drug-binding protein, respectively.
Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein.
The study characterizes MRD as a quinone reductase that can transform mitomycin C (MC) into mitosenes, and identifies the E55G mutation in MRD that increases MC resistance in E. coli.
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