mreE

penicillin binding protein 2 (PBP2)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mreE

Browse AMR rules for mreE

Overview

Mechanism: penicillin-binding protein MreE
Drug Classes: ampicillin|ceftriaxone|cefoxitin|cephalexin|cefoperazone|cefepime, cephalosporins
Organisms: Clostridioides difficile
Papers: 1
Mutations: 9

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V497L	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
A778V	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
A795V	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
Y721S	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
Y721C	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
A694V	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
M496V	-	penicillin-binding protein MreE	Clostridioides difficile	ampicillin\|ceftriaxone\|cefoxitin\|cephalexin\|cefoperazone\|cefepimecephalosporins	ReslitReference Gene Catalog	Candidate
A694T	-	penicillin-binding protein MreE	Clostridioides difficile	cephalosporins	Reference Gene Catalog	Candidate
A795L	-	penicillin-binding protein MreE	Clostridioides difficile	cephalosporins	Reference Gene Catalog	Candidate

Papers1

1

Clostridioides difficile MreE (PBP2) variants facilitate clinical disease during cephalosporin exposures.

PMID 37961251 · 2023

mutations in mreE confer resistance to beta-lactam antibiotics

mreE

Mutation Information

mreE: p.V497L mreE: p.A778V mreE: p.A795V mreE: p.Y721S mreE: p.Y721C mreE: p.A694V mreE: p.M496V mreE: p.A694T mreE: p.A795L

Protein Change: V497L, A778V, A795V, Y721S, Y721C, A694V, M496V, A694T, A795L
Organisms: Clostridioides difficile
Confers Resistance To: ampicillin|ceftriaxone|cefoxitin|cephalexin|cefoperazone|cefepimecephalosporins
Effect on Function: penicillin-binding protein MreE
Validation Method: transfer of variants into susceptible strain CD630
Source Database: ReslitReference Gene Catalog