mrp4

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efflux transporter

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UniProt

Protein entries specific to mrp4

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Validation StatusCandidate

Overview

Validation Method: silencing experiments and mRNA expression analysis
Drug Classes: ciprofloxacin
Papers: 1
Databases: Reslit

Papers1

Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.

PMID 19307362 · 2009

The study identifies Mrp4 as the primary efflux transporter responsible for ciprofloxacin resistance in murine J774 macrophages, demonstrated through overexpression in resistant cells and silencing experiments that increased ciprofloxacin accumulation.

Gene Information

Gene Name: mrp4
Allele: Mrp4
Encodes: efflux transporter
Source Database: Reslit
Confers Resistance To: ciprofloxacin
Validation Method: silencing experiments and mRNA expression analysis

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mrp4

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mrp4

Gene Information