Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
msr-type ABC-F protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| msr(A) | Card DatabaseResFinder Database | 2 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Staphylococcus epidermidis +1 | - | 1990 | X52085.1 | CAA36304.1 |
| msrA | Reslit | 86 | macrolides, streptogramins +6 | Staphylococcus aureus +48 | France, Europe|North America|Asia, United States, New York|Pennsylvania, Colombia, Spain, Turkey, United States|Afghanistan, Japan, Poland, Nigeria, Iran, Germany, Kuwait, Malaysia, Egypt, London, UK, Michigan, USA, East London|West London, Kenya, Maputo, Mozambique, India, Spain|Italy, China, Sardinia, Italy|Italy, Western Uganda, Novosibirsk, Russia, Europe, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Saudi Arabia, Somalia|Kenya|East Africa, Eastern Switzerland, Tunisia, Italy, Guangzhou, China, Swiss Canton Tessin|various herds|Switzerland, Brazil, USA, Slovakia, Alexandria, Egypt, Europe|Spain, Pakistan, global, Vietnam, Delhi, India, Peninsular Malaysia|Malaysia | 1996, 1999, 2003, 2005, 2006, 2007, 2010, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AY534326|EFU01917 | - |
| Msr(A) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 26 | ERYTHROMYCIN, STREPTOGRAMIN B +13 | Staphylococcus aureus +11 | Turkey, Iran, Gambia, Denmark, Pacific region|Hawaii, Korea, South Africa, China, Benin, Algeria, North America|South America|Europe|Asia|Africa, Egypt | 1998, 1999, 2005, 2006, 2007, 2010, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AB016613.1 | BAA88415.1 |
| MsrA | Reslit | 3 | macrolides, ketolides +1 | Staphylococcus aureus +1 | - | 2009, 2021, 2023 | - | - |
| msr(A)/msr(B) | Reslit | 1 | erythromycin, azithromycin | Staphylococcus aureus +1 | China | 2015 | - | - |
| msra | Reslit | 1 | erythromycin | Staphylococcus aureus | - | 2016 | - | - |
| msr | Reslit | 7 | azithromycin, macrolides +1 | Staphylococcus aureus +7 | The Gambia, USA|France|Portugal|China|Brazil|Germany|Sweden|Italy|Spain|Denmark|Japan|Korea|Europe|Asia|North America, Norway, India, Hangzhou, China, Japan | 2017, 2018, 2021, 2022, 2023, 2024 | MZ955857|MZ955858|MZ955859|MZ955860|MZ955862|MZ955863 | - |
| msr A | Reslit | 2 | erythromycin, macrolides | Staphylococcus epidermidis +2 | Thailand | 2019, 2024 | - | - |
Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.
The study identified and characterized various AMR genes, including ermA, ermC, msrA, linA/linA′, vga, vgb, and vat, which confer resistance to macrolides, lincosamides, and streptogramins in staphylococci.
Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci.
The study identifies and characterizes the genes ermA, ermC, and msrA responsible for inducible and constitutive clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci using PCR and disk diffusion testing.
Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.
The study identifies ermA, ermC, and msrA as genes responsible for clindamycin resistance in erythromycin-resistant Staphylococcus aureus isolates, with distinct phenotypes observed in disk diffusion testing.
Efflux-mediated antimicrobial resistance.
Efflux-mediated antimicrobial resistance.
Efflux-mediated antimicrobial resistance.
Characterization of a Strain of Community-Associated Methicillin-Resistant Staphylococcus aureus Widely Disseminated in the United States
The study characterizes a community-associated methicillin-resistant Staphylococcus aureus strain (USA300-0114) that exhibits resistance to multiple antibiotics, including penicillin, oxacillin, erythromycin, tetracycline, and fluoroquinolones. Key resistance genes identified include blaZ, msrA, mecA, tet(K), and ermC, along with the Panton-Valentine leucocidin toxin genes lukF-PV and lukS-PV.
Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates.
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
The study identifies vanA, tet(S), and tet(U) as key genes contributing to vancomycin and tetracycline resistance in VRSA isolates, highlighting the role of plasmid-mediated gene transfer in the emergence of multidrug-resistant Staphylococcus aureus.
Community-associated methicillin-resistant Staphylococcus aureus, Colombia.
Two cases of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) were identified in Colombia, with the isolates showing resistance to specific antibiotics and carrying the mecA and msrA genes.
Use of a DNA microarray for simultaneous detection of antibiotic resistance genes among staphylococcal clinical isolates.
The study developed a DNA microarray for the simultaneous detection of antibiotic resistance genes in staphylococcal clinical isolates, identifying genes such as mecA, blaZ, aac(6')-Ie-aph(2''), ermA, ermC, and msrA, which confer resistance to methicillin, penicillin, gentamicin, erythromycin, clindamycin, and macrolides/streptogramin B.
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Distribution of genes encoding resistance to macrolides, lincosamides and streptogramins among clinical staphylococcal isolates in a Turkish university hospital.
The study identified the prevalence of erm(A), erm(C), msr(A), and msr(B) genes in erythromycin-resistant staphylococcal isolates, highlighting geographical variations in resistance mechanisms.
Genotypes, exotoxin gene content, and antimicrobial resistance of Staphylococcus aureus strains recovered from foods and food handlers.
The study identified various AMR genes in S. aureus strains from foods and food handlers, including blaZ, mupA, ermC, msrB, msrA, aacA, aphD, aadD, and tetK, which confer resistance to beta-lactams, mupirocin, erythromycin, clindamycin, aminoglycosides, and tetracycline.
Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family., A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan.
The study identified several AMR genes in MRSA and MSSA isolates, including ermC, tetK, tetM, blaZ, msrA, and ermA, which confer resistance to clindamycin, tetracycline, penicillin, and erythromycin. These findings highlight the genetic basis of antimicrobial resistance in S. aureus isolates from military personnel in the US and Afghanistan.
Emergence of Staphylococcus aureus carrying multiple drug resistance genes on a plasmid encoding exfoliative toxin B.
The study identifies the presence of multiple drug resistance genes on a plasmid encoding exfoliative toxin B in Staphylococcus aureus, including aac(6')-aph(2"), msrA, and blaZ, which confer resistance to gentamicin, kanamycin, tobramycin, erythromycin, and penicillin.
Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.
Prevalence of antibiotic resistance in multi-drug resistant coagulase-negative staphylococci isolated from invasive infection in very low birth weight neonates in two Polish NICUs.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CNS) isolated from very low birth weight neonates, including mecA, ermC, msrA, aac(6')/aph(2''), and aph(3')-IIIa, which conferred resistance to methicillin, erythromycin, clindamycin, gentamicin, and amikacin.
Diversity of antibiotic resistance genes and staphylococcal cassette chromosome mec elements in faecal isolates of coagulase-negative staphylococci from Nigeria.
The study identified several antibiotic resistance genes, including aac(6')-aph(2"), ermC, msrA, tetK, tetM, and mecA, in faecal isolates of coagulase-negative staphylococci from Nigeria. These genes were associated with resistance to gentamicin, erythromycin, and tetracycline, as well as methicillin resistance.
Meticillin-resistant Staphylococcus aureus isolated from Iranian hospitals: virulence factors and antibiotic resistance properties.
The study identified several AMR genes in meticillin-resistant Staphylococcus aureus (MRSA) isolates from Iranian hospitals, including mecA, tetK, ermA, ermC, aacA-D, linA, msrA, vatA, vatC, and vatB. Additionally, the Panton-Valentine leukocidin (PVL) gene was found in 40.9% of the isolates.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive Staphylococcus aureus and coagulase-negative staphylococcal isolates from bovine mastitis.
The study identified various MLS resistance genes, including erm(C), mph(C), erm(B), ere(A), vga(A), lnu(A), and msr(A)/msr(B), in Staphylococcus aureus and coagulase-negative staphylococci isolates from bovine mastitis, highlighting a high prevalence of inducible MLS resistance.
Impact of a Probiotic-Based Cleaning Intervention on the Microbiota Ecosystem of the Hospital Surfaces: Focus on the Resistome Remodulation.
The study found that PCHS-Bacillus strains exhibited resistance to penicillins and macrolides through the presence of OXA group beta-lactamase and msrA macrolide resistance efflux pump genes. Importantly, these Bacillus strains did not acquire new resistance genes during the study period.
The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis.
The study identified the prevalence of genes responsible for MLSB resistance in erythromycin-resistant S. epidermidis, highlighting the frequent occurrence of ermC, mphC, msrA, and linA/A'.
Distribution of Genes Encoding Resistance to Macrolides Among Staphylococci Isolated From the Nasal Cavity of Hospital Employees in Khorramabad, Iran.
The study identified the presence of ermA, ermB, ermC, and msrA genes in Staphylococcus isolates from hospital employees, highlighting the prevalence of macrolide resistance mechanisms in both S. aureus and coagulase-negative staphylococci.
Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps.
Cholecalciferol and alpha-tocopherol were found to inhibit efflux pumps in Staphylococcus aureus strains, reducing the MIC of antibiotics. Specifically, cholecalciferol showed significant modulation of tetracycline activity against the IS-58 strain.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
A Low Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B Resistance Phenotype among Methicillin-Susceptible Staphylococcus aureus Isolated from Malaysian Patients and Healthy Individuals.
The study found a low prevalence of inducible MLSB (iMLSB) and MS resistance phenotypes among methicillin-susceptible Staphylococcus aureus (MSSA) isolates in Malaysia. The ermC gene was detected in all iMLSB isolates, while the msrA gene was found in the MS isolate.
Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control.
The study identified the presence of macrolide resistance genes msr, erm(C), and erm(T) in Staphylococcus aureus isolates following mass drug administration with azithromycin, contributing to increased prevalence of macrolide-resistant strains.
Phenotypic and genotypic characterization of antibiotic resistance of methicillin-resistant Staphylococcus aureus isolated from hospital food.
The study identified tetK, ermA, msrA, and aacA-D as the most common antibiotic resistance genes in MRSA strains isolated from hospital food samples, highlighting the potential public health threat posed by multidrug-resistant MRSA.
Polymerase chain reaction detection of genes responsible for multiple antibiotic resistance Staphylococcus aureus isolated from food of animal origin in Egypt.
The study identified several antibiotic resistance genes in multiple drug-resistant Staphylococcus aureus isolates from food of animal origin in Egypt, including blaZ, tetK, ermB, msrA, ermC, and aac(6')-aph(2").
Linking the Effect of Antibiotics on Partial-Nitritation Biofilters: Performance, Microbial Communities and Microbial Activities.
The study identified several genes associated with antibiotic resistance in a partial-nitritation biofilter exposed to a mixture of antibiotics. These included ermF, carA, and msrA for azithromycin resistance, gyrA and grlB mutations for norfloxacin resistance, and sul123 for sulfamethoxazole resistance.
Characterization of resistance to selected antibiotics and Panton-Valentine leukocidin-positive Staphylococcus aureus in a healthy student population at a Malaysian University.
The study identified blaZ, msrA, and ermC genes as responsible for penicillin and erythromycin resistance in Staphylococcus aureus isolates from healthy students in Malaysia.
Antimicrobial Resistance in Streptococcus spp.
The paper discusses the prevalence and mechanisms of antimicrobial resistance in Streptococcus species, particularly focusing on macrolide, lincosamide, and tetracycline resistance. Key genes identified include erm(B), erm(A), lnuB, lnuD, mefA, mefE, msr, tet(B), tet(K), tet(L), tet(M), tet(O), and tet(S).
Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59.
The study identifies several antibiotic resistance genes in the multidrug-resistant S. epidermidis strain G6_2, including aac(6')-aph(2"), blaZ, mecA, fosB, mphC, msrA, tetK, and qacC, which confer resistance to various antibiotics. Additionally, point mutations in ileS and fusA are associated with resistance to mupirocin and fusidic acid.
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens.
The study characterizes various AMR genes involved in resistance to multiple antibiotics, including beta-lactams, aminoglycosides, macrolides, tetracyclines, and others, in different bacterial species such as Staphylococcus aureus, Enterococcus faecium, and Serratia marcescens.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Genetic Diversity Analysis of Methicillin-resistant Staphylococcus aureus Strains Isolated from Intensive Care Unit in Iran.
The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin.
The study identifies msr(A) as the main macrolide resistance gene in azithromycin-resistant Staphylococcus aureus isolates from Gambian mothers and newborns, with the gene located on an MDR plasmid in ST5 MSSA strains.
Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990-2017.
The study characterizes the antimicrobial resistance profiles of Staphylococcus aureus clinical isolates in Malaysia, highlighting the presence of mecA gene conferring beta-lactam resistance and erm gene contributing to MLSB resistance.
Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus.
The study identifies RP2, a microbial-derived indole metabolite, as a potent efflux pump inhibitor targeting NorA, TetK, and MsrA in Staphylococcus aureus, enhancing the efficacy of antibiotics by reducing their minimum inhibitory concentrations and preventing the emergence of resistant mutants.
Phenotypic and genotypic characterization of clinical Staphylococcus aureus isolates from Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Kenyan Staphylococcus aureus isolates, including mecA, ant(4')-lb, aph(3')-IIIa, ermA, sat-4, fusA, mphC, msrA, gyrA (S84L), parC (S80F), and rpoB mutations, highlighting the presence of multidrug-resistant strains.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis.
The study identified that Trp-containing peptides synergistically enhance the antibacterial activity of antibiotics against multidrug-resistant Staphylococcus epidermidis by reducing the expression of resistance genes such as bla Z, tet(m), and msr A.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Baicalin Inhibits Biofilm Formation and the Quorum-Sensing System by Regulating the MsrA Drug Efflux Pump in Staphylococcus saprophyticus.
Baicalin inhibits the MsrA efflux pump, biofilm formation, and the agr quorum-sensing system in Staphylococcus saprophyticus.
Molecular characterization of methicillin-resistant Staphylococcus aureus clinical strains from the endotracheal tubes of patients with nosocomial pneumonia.
The study identified various AMR genes and mutations in MRSA strains from endotracheal tubes, including ermC, ermA, msrA, aac(6')-aph(2"), tetK, and fusB, along with quinolone resistance mutations in gyrA, gyrB, grlA, and grlB.
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque.
The study identified multiple AMR genes in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates from dental plaque, including mecA, dfrA, dfrG, aacA-aphD, aadD, aphA3, ermC, msrA, tetK, norA, qacA, and qacC. These genes confer resistance to various antibiotics such as oxacillin, penicillin G, trimethoprim, gentamicin, erythromycin, tetracycline, and quaternary ammonium compounds.
Determining the Genetic Characteristics of Resistance and Virulence of the "Epidermidis Cluster Group" Through Pan-Genome Analysis.
Two resistance genes, aadD2 and blaZ, were identified in S. caprae SY333 and experimentally validated for their roles in conferring resistance to aminoglycosides and beta-lactams, respectively.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Comparative characterisation of human and ovine non-aureus staphylococci isolated in Sardinia (Italy) for antimicrobial susceptibility profiles and resistance genes.
The study identified various AMR genes in non-aureus staphylococci from ovine and human sources, including blaZ, tetK, msrA, ermC, smr, and qacA/B, which confer resistance to penicillin, tetracycline, erythromycin, and antiseptics.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow's Milk in Kenya.
The study identified several antimicrobial resistance genes in staphylococci isolated from mastitic cow's milk in Kenya, including blaZ, strB, msrA, ermB, tetM, and tetK, which confer resistance to beta-lactams, streptomycin, erythromycin, and tetracycline.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Association of Macrolide Resistance Genotypes and Synergistic Antibiotic Combinations for Combating Macrolide-Resistant MRSA Recovered from Hospitalized Patients.
The study identified the presence of ermA, ermC, and msrA genes in macrolide-resistant MRSA isolates, which contribute to resistance against macrolide antibiotics. The presence of these genes was associated with synergistic effects when combined with other antibiotics like linezolid, ceftriaxone, and gentamicin.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Functional screening of a human saliva metagenomic DNA reveal novel resistance genes against sodium hypochlorite and chlorhexidine.
The study identified novel resistance genes against sodium hypochlorite and chlorhexidine, including accB and recA, along with previously known genes such as msr, mef(A), tetAB(46), and fabK.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistant Staphylococcus aureus (MRSA) isolated from pets and pet owners in Malaysia.
The study identified multiple AMR genes including mecA, tetK, tetL, ermA, ermB, ermC, msrA, scn, chp, sak, sea, and sep in S. aureus isolates from pets and pet owners in Malaysia, indicating the presence of multidrug-resistant and methicillin-resistant strains.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Genetic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates from India: Identification of Resistance Islands and Mobile Genetic Elements
This study identified various AMR genes including blaOXA-23, blaNDM-1, aph(3')-Ib, aph(6)-Id, armA, mph, msr, cmlA1, ARR-2, sul1, sul2, tet(B), and blaPER-7 in carbapenem-resistant Acinetobacter baumannii isolates from India. These genes were found to be associated with resistance islands and mobile genetic elements, contributing to the spread of multidrug resistance.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Application of MinION sequencing as a tool for the rapid detection and characterization of Listeria monocytogenes in smoked salmon.
The study identified five antimicrobial resistance genes (norB, msrA, mprF, mepA, and FosX) in Listeria monocytogenes strains using MinION sequencing and the CARD database.
Transcriptomic analysis of Staphylococcus equorum KM1031 from the high-salt fermented seafood jeotgal under chloramphenicol, erythromycin and lincomycin stresses.
The study identifies abm, msr, and lnuA as genes contributing to chloramphenicol, erythromycin, and lincomycin resistance in Staphylococcus equorum KM1031, respectively.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Outbreak investigation including molecular characterization of community associated methicillin-resistant Staphylococcus aureus in a primary and secondary school in Eastern Switzerland.
The study identified a cluster of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in a school in Eastern Switzerland, characterized by ST5 sequence type and efflux-mediated macrolide resistance. The outbreak was linked to a local school, and decolonization efforts successfully reduced the incidence of CA-MRSA cases.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
Genomic Characterization of a Vancomycin-Resistant Strain of Enterococcus faecium Harboring a rep2 Plasmid.
The study identified a vancomycin-resistant Enterococcus faecium strain (SJ2) harboring the vanA gene on a rep2 plasmid. The strain exhibited resistance to multiple antibiotics, including vancomycin, and contained several other antimicrobial resistance genes.
Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates.
The study identified several AMR genes associated with erythromycin and clindamycin resistance in Staphylococcus aureus, including ermC, ermA, ermB, msrA, msrB, lnuA, and mphC. These genes were detected through PCR and phenotypic analysis.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates.
The study identified linezolid resistance mechanisms in MRSA isolates, including mutations in domain V of 23 S rRNA (A2338T, T2504C, G2576T) and genes such as cfr(B), optrA, msrA, mecA, and vanA.
Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.
The study evaluated the effectiveness of a combined probiotic-phage sanitation system (PCHSφ) in reducing microbial contamination and antimicrobial resistance (AMR) in hospital environments. PCHSφ significantly reduced staphylococcal contamination and AMR gene prevalence compared to conventional chemical disinfection and PCHS alone.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Prevalence and antibiotic resistance of Staphylococcus aureus associated with a college-aged cohort: life-style factors that contribute to nasal carriage.
The study identified several AMR genes in S. aureus isolates, including blaZ, mecA, tetM, dfrS1, ermA, ermC, msrA, and norA, which conferred resistance to penicillin, cefoxitin, tetracycline, trimethoprim, azithromycin, and ciprofloxacin.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Baseline azithromycin resistance in the gut microbiota of preterm born infants.
The study identifies the presence of macrolide resistance genes in the gut microbiota of preterm infants, with erm(C) and msr(A) being the most common. These genes were found in various bacterial genera, including Staphylococcus and Enterococcus.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains.
Valencene and nootkatone were identified as potential inhibitors of the NorA, Tet(K), MsrA, and MepA efflux pumps in Staphylococcus aureus strains, reducing the MIC of antibiotics and increasing EtBr fluorescence emission, indicating efflux pump inhibition.
Multidrug Efflux System-mediated resistance in Staphylococcus aureus under a One Health approach.
The study identifies several multidrug efflux system genes (norA, norB, norC, lmrS, tet38, msrA) in Staphylococcus aureus isolates from human, animal, and food sources, highlighting their role in resistance to various antibiotics.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations.
The study identified that the sesquiterpenes nerolidol, farnesol, and alpha-bisabolol inhibited efflux pumps NorA, Tet(K), MsrA, and MepA in Staphylococcus aureus strains, reducing the minimum inhibitory concentration (MIC) of antibiotics and enhancing their antibacterial activity.
Macrolide-Lincosamide Resistance and Virulence Genes in Staphylococcus aureus Isolated from Clinical Specimens in Ardabil, Iran.
The study identified high frequencies of erythromycin and clindamycin resistance in Staphylococcus aureus isolates from Ardabil, Iran, with ermC being the most prevalent erythromycin resistance gene.
Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.
The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.
Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K(3).
The study identified several macrolide resistance genes, including erm(A), erm(B), erm(C), msr(A), and mph(C), in Staphylococcus aureus isolates. These genes were associated with resistance to erythromycin and azithromycin.
Comparative genomic analysis of antibiotic resistance and virulence genes in Staphylococcus aureus isolates from patients and retail meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Virulence determinants and antibiotic resistance in staphylococci isolated from the skin of captive bred reptiles.
The study identified several AMR genes in staphylococci isolated from the skin of captive-bred reptiles, including blaZ, dfrK, dfrA(S1), tetK, msrA, mecA, and mecC. These genes conferred resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim, tetracycline, erythromycin, and cephalosporins. The study highlights the prevalence of multidrug resistance among these isolates.
Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions.
The study identifies prophage-encoded antibiotic resistance genes, including aadK in Paenibacillus polymyxa and mph(C) and msr(A) in Staphylococcus epidermidis, highlighting the role of bacteriophages in microbial adaptation to spaceflight.
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Phenotypic and genotypic characterization of commensal staphylococci isolated from young volunteers in Alexandria, Egypt.
The study identified the presence of macrolide resistance genes ermB, ermC, and msrA in Staphylococcus aureus and other staphylococci (SOSA) isolates, with ermB showing the highest prevalence. These genes confer resistance to erythromycin and azithromycin.
Investigation of antimicrobial resistance and antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit.
The study identified multiple antimicrobial resistance genes, including bla Z, aac A- aph D, msr A, tet K, gyr A, grl A, dfr G, and cfr, in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit clinical abscesses, highlighting the presence of multidrug-resistant strains.
Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
The study identifies several antibiotic resistance genes and mutations in Staphylococcus aureus isolates associated with increased resistance to methicillin, macrolides, and other antibiotics during the COVID-19 pandemic.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci.
Mapping Antimicrobial Resistance in Staphylococcus epidermidis Isolates from Subclinical Mastitis in Danish Dairy Cows.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis isolates from subclinical mastitis in Danish dairy cows, including blaZ for penicillin resistance, fosB for fosfomycin resistance, msr(A) and mph(C) for erythromycin resistance, and tet(K) for tetracycline resistance.
Staphylococcus epidermidis: Antimicrobial Resistance Profiles of Biofilm-Forming Isolates From Pediatric Bacteremia in Pakistan.
The study identified mecA, msrA, and blaZ genes in biofilm-forming Staphylococcus epidermidis isolates from pediatric bacteremia, showing high prevalence of methicillin, erythromycin, and beta-lactam resistance.
Phenotypic and genotypic characteristics of macrolide, lacosamide, and streptogramin resistance in clinically resistant Streptococci and their correlation with reduced biocide susceptibility.
The study identifies ermB, ereA, msrA, mefA, and mefE as key genes associated with MLS resistance in Streptococci, highlighting the role of efflux mechanisms and ribosomal methylation in conferring resistance to macrolides, lincosamides, and streptogramins.
Antimicrobial Resistant Staphylococcus spp., Escherichia coli, and Salmonella spp. in Food Handlers: A Global Review of Persistence, Transmission, and Mitigation Challenges.
The study highlights the prevalence of antimicrobial resistance in Staphylococcus spp., Escherichia coli, and Salmonella spp. isolated from food handlers, emphasizing the role of genes such as mecA, blaZ, msrA, linA, and fusB in conferring resistance to various antibiotics.
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.
The study identified novel Staphylococcal cassette chromosome mec (SCC mec ) elements in four methicillin-resistant coagulase-negative Staphylococci (CoNS) isolates from healthy medical students. The isolates harbored various antimicrobial resistance genes, including mecA, blaZ, mphC, msrA, tetK, fusC, fusF, qacA, qacB, qacC, norA, copB, arsC, cadC, cadD, copZ, copA, copR, and czcD, which conferred resistance to beta-lactams, macrolides, tetracyclines, fusidic acid, quaternary ammonium compounds, fluoroquinolones, and heavy metals.
Prevalence, species identification, and antibiotic resistance of Staphylococci in dogs visiting veterinary clinics in Vietnam.
The study identified several antibiotic resistance genes in Staphylococcus isolates from dogs in Vietnam, including aacA-aphD, tetK, gyrA, mecA, msrA, dfrA, and ermA, highlighting the prevalence of multidrug-resistant Staphylococcus species.
Pristinamycin-antibiotic combinations against methicillin-resistant Staphylococcus aureus recovered from skin infections.
The study identifies the presence of ermA, ermC, msrA, and mecA genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates, contributing to resistance against macrolides, lincosamides, streptogramin B, and beta-lactams. It also evaluates the effectiveness of pristinamycin combinations with other antibiotics against these resistant isolates.
Whole genome sequence of multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment reveals evolving infection potential and resistance.
The study identified multiple antibiotic resistance genes in multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment, highlighting their potential to resist various antibiotics and posing a health risk in communal environments.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Genomic diversity and antimicrobial resistance of Staphylococcus aureus in Saudi Arabia: a nationwide study using whole-genome sequencing.
The study identified multiple AMR genes in S. aureus isolates from Saudi Arabia, highlighting the genetic diversity and resistance patterns associated with mass gatherings. Key genes include mecA, mecR1, aacA-aphD, knt, tet(K), ermC, msrA, fcl_1, natA, macB, and dppB, which confer resistance to various antibiotics.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Distribution and antibiotic resistance patterns of airborne staphylococci in urban environments of Delhi, India.
The study identified multiple antibiotic resistance genes (ARGs) in airborne staphylococci, including mecA, dfrS1(dfrA), dfrG, femB, blaZ, cfr, and msrA, which confer resistance to methicillin, trimethoprim, beta-lactams, chloramphenicol, and macrolides/lincosamides. High prevalence of multidrug-resistant staphylococci was observed in urban environments of Delhi, India.
Genomic Insights into Multidrug-resistant Mammaliicoccus sciuri Carrying Novel Staphylococcal Cassette Chromosome mec (SCCmec) Elements and Plasmids from Farm Ruminants on the East Coast of Peninsular Malaysia.
The study identified multiple antimicrobial resistance genes in four multidrug-resistant Mammaliicoccus sciuri isolates from farm ruminants in Peninsular Malaysia, including mecA, ermY, mphC, msrA, tetL, tetS, aadD, ant(6)-Ia, aac(6')-Ie-aph(2")-Ia, fexA, icaA, icaB, icaC, icaD, icaR, sspA, ndk, and lgt. These genes confer resistance to various antibiotics, including β-lactams, macrolides, tetracyclines, aminoglycosides, and chloramphenicol.
Staphylococcus aureus in commercial laying hens from Pernambuco, Brazil: detection of efflux pumps and β-lactam resistance genes.
The study detected β-lactam resistance gene blaZ and methicillin resistance gene mecC, along with efflux pump genes norA, norC, and msrA in Staphylococcus aureus isolates from commercial laying hens in Brazil.
Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220.
The study shows that the msrA gene, encoding an ABC-transporter, is sufficient for erythromycin and type B streptogramin resistance in Staphylococcus aureus RN4220. Deletion of the control region of msrA resulted in constitutive resistance, demonstrating that the gene's wild-type form confers resistance without requiring additional chromosomal sequences.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
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