msra/d

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macrolide phosphotransferase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to msra/d

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Validation StatusCandidate

Overview

Validation Method: genotypic characterization
Drug Classes: macrolides
Organisms: Klebsiella pneumoniae
Geographic Location: China
Papers: 1
Databases: Reslit

Papers1

Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae.

PMID 40835923 · 2025

The study identifies two lytic bacteriophages, vB_KpnP_XY3 and vB_KpnP_XY4, effective against multidrug-resistant Klebsiella pneumoniae. These phages demonstrate broad temperature and pH tolerance, chloroform resistance, and potent lytic activity against MDR K. pneumoniae strains, significantly reducing bacterial load and inflammation in a murine pneumonia model.

Gene Information

Gene Name: msra/d
Allele: msrA/D
Encodes: macrolide phosphotransferase
Source Database: Reslit
Confers Resistance To: macrolides
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: China
Validation Method: genotypic characterization
Sequence Accession: CCTCC M 2025022|CCTCC M 2025094|BankIt2933679|Seq1 PV296009|BankIt2936412|Seq1 PV296010

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msra/d

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msra/d

Gene Information