Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G924P | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| P927G | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| N917C | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| G924C | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| P927C | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| 917-927del | - | - | Neisseria gonorrhoeae | ampicillin | Reslit | Candidate |
| F136A | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| F176A | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| I605A | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| F610A | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| S611A | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| F612C | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| F623C | - | - | - | erythromycin|novobiocin|tigecycline|ciprofloxacin|benzalkonium chloride|chlorhexidine|triclosan|colistin | Reslit | Candidate |
| S821A | - | gain-of-function | Neisseria gonorrhoeae | azithromycin|erythromycinmacrolidesazithromycin | Reslit | Candidate |
| K823E | - | gain-of-function, multidrug efflux RND transporter permease subunit MtrD | Neisseria gonorrhoeae | azithromycin|erythromycinmacrolidesazithromycin+1 more | ReslitReference Gene Catalog | Candidate |
| K823G | - | - | Neisseria gonorrhoeae | azithromycin | Reslit | Candidate |
| E823K | - | - | Neisseria canis | azithromycin | Reslit | Candidate |
| R174G | - | - | - | macrolides | Reslit | Candidate |
| E669G | - | - | - | macrolides|polymyxin b | Reslit | Candidate |
| R714G | - | - | - | macrolides | Reslit | Candidate |
| M570K | - | - | Neisseria gonorrhoeae | cefixime | Reslit | Candidate |
| R714C | - | multidrug efflux RND transporter permease subunit MtrD | Neisseria gonorrhoeae | azithromycin | Reference Gene Catalog | Candidate |
| R714H | - | multidrug efflux RND transporter permease subunit MtrD | Neisseria gonorrhoeae | azithromycin | Reference Gene Catalog | Candidate |
| R714L | - | multidrug efflux RND transporter permease subunit MtrD | Neisseria gonorrhoeae | azithromycin | Reference Gene Catalog | Candidate |
| K823N | - | multidrug efflux RND transporter permease subunit MtrD | Neisseria gonorrhoeae | azithromycin | Reference Gene Catalog | Candidate |
Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.
The study identifies that an mtrR mutation leads to overexpression of the MtrC-MtrD-MtrE efflux pump, which is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Additionally, insertional inactivation of mtrD reduces resistance to penicillin and tetracycline.
Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump.
The study identifies the MtrCDE efflux pump components and characterizes the E434K mutation in MtrE as critical for vancomycin resistance, demonstrating that energy-dependent proton translocation is required for pump function.
Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.
The study identifies mtrD and mtrR as key genes contributing to azithromycin resistance in Neisseria gonorrhoeae through epistatic interactions. Mutations in mtrR, including G45D and C2611T, enhance resistance when combined with mosaic mtrD alleles.
Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
The study identifies key amino acid residues in the MtrD multidrug efflux pump of Neisseria gonorrhoeae that are critical for drug resistance, particularly to macrolides and beta-lactams.
PARMAP: A Pan-Genome-Based Computational Framework for Predicting Antimicrobial Resistance and Identifying Resistance-Associated Genetic Alterations
PARMAP, a pan-genome-based computational framework, successfully predicts antimicrobial resistance in Neisseria gonorrhoeae, Mycobacterium tuberculosis, and Escherichia coli. It identifies both known and novel AMR-associated gene alleles, including mutations in genes like GYRA, GYRB, ACNB, and PDXJ, which are linked to ciprofloxacin resistance.
Azithromycin Susceptibility Testing and Molecular Investigation of Neisseria gonorrhoeae Isolates Collected in Russia, 2020-2021.
The study identified mutations in the mtrR and mtrD genes of the MtrCDE efflux pump as the primary mechanism of azithromycin resistance in N. gonorrhoeae isolates from Russia.
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