Mutations in the mtrR gene, including a promoter region deletion and a missense mutation at codon 45, lead to decreased azithromycin susceptibility in Neisseria gonorrhoeae by overexpressing the mtrCDE efflux pump.

The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.

The study characterizes various AMR genes and mutations in Neisseria gonorrhoeae, highlighting the emergence of resistance to multiple antimicrobials over time, including penicillin, fluoroquinolones, macrolides, tetracyclines, and sulfonamides. Key findings include the identification of penB, mtrR, penA, gyrA, parC, folP, rpsJ, tetM, and blaTEM as critical AMR genes, along with mutations in penB, mtrR, gyrA, parC, penA, and ponA that contribute to resistance mechanisms.

PARMAP, a pan-genome-based computational framework, successfully predicts antimicrobial resistance in Neisseria gonorrhoeae, Mycobacterium tuberculosis, and Escherichia coli. It identifies both known and novel AMR-associated gene alleles, including mutations in genes like GYRA, GYRB, ACNB, and PDXJ, which are linked to ciprofloxacin resistance.

The study identifies mutations in the mtrR gene that disrupt DNA binding and increase resistance to macrolides and cationic antimicrobial peptides in Neisseria gonorrhoeae.

The study identified multiple AMR genes and mutations in Neisseria gonorrhoeae isolates from KwaZulu-Natal, South Africa, including blaTEM, penA_ins346D, ponA_L421P, mtrR_G45D, porB1b_G120K, porB1b_A121N, mtrR_disrupted, tetM, rpsJ_V57M, gyrA_S91F, gyrA_D95G, gyrA_D95A, parC_D86N, S87N, and S87I, which confer resistance to penicillin, tetracycline, and ciprofloxacin.

Exposure to sub-lethal chlorhexidine concentrations induced resistance to chlorhexidine and cross-resistance to other antibiotics in Neisseria gonorrhoeae. Mutations in norM, mtrR, and mlaA were associated with increased chlorhexidine resistance.

The study identified several AMR genes and mutations in N. gonorrhoeae, including bla TEM, tetM, rpsJ_V57M, gyrA_S91F, 16S_rRNA_C1192U, mtrR_G45D, penA_G545S, and penA_mosaic, which are associated with resistance to penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin, cefixime, and ceftriaxone.

The paper discusses the identification of genetic markers associated with resistance to ciprofloxacin, cefixime, and ceftriaxone in Neisseria gonorrhoeae, highlighting the development of molecular assays for resistance-guided therapy.

The paper discusses the development and evaluation of new antimicrobial agents against Neisseria gonorrhoeae, highlighting the importance of monitoring resistance mechanisms such as mutations in GyrA and ParC that confer resistance to fluoroquinolones.

The study identified mutations in the mtrR and mtrD genes of the MtrCDE efflux pump as the primary mechanism of azithromycin resistance in N. gonorrhoeae isolates from Russia.

The study identifies penA, mtrR, and porB as key genes involved in β-lactam resistance in Neisseria gonorrhoeae. Mutations in penA, mtrR, and porB contribute to reduced susceptibility to cephalosporins, beta-lactams, macrolides, and tetracyclines.

The study identifies mutations in gyrA, gyrB, mtrR, parC, and parE that confer ciprofloxacin resistance in Neisseria commensals. These mutations were validated through whole genome sequencing and MIC testing.

The study identifies mutations in MtrR (A46T), rpsJ (V57M), and rplX (A14T) associated with doxycycline resistance in Neisseria commensals, as well as the presence of the tetM gene in high-level resistant isolates.