murAB

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UDP-N-acetylmuramate--alanine ligase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to murAB

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: Physical interaction with IreB, promoting proteolysis of MurAA
Validation Method: Thermal shift assays, bacterial two-hybrid assays
Drug Classes: ceftriaxone
Organisms: Enterococcus faecalis
Papers: 1
Databases: Reslit

Papers1

PASTA-kinase-mediated signaling drives accumulation of the peptidoglycan synthesis protein MurAA to promote cephalosporin resistance in Enterococcus faecalis.

PMID 37688380 · 2023

The study identifies point mutations in murAA (A115T, A115V, N188K) that enhance ceftriaxone resistance in Enterococcus faecalis by stabilizing MurAA and disrupting its interaction with IreB, highlighting the role of MurAA in cephalosporin resistance.

Gene Information

Gene Name: murAB
Allele: murAB
Encodes: UDP-N-acetylmuramate--alanine ligase
Source Database: Reslit
Mechanism: Physical interaction with IreB, promoting proteolysis of MurAA
Confers Resistance To: ceftriaxone
Organisms Tested In: • Enterococcus faecalis
Validation Method: Thermal shift assays, bacterial two-hybrid assays

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murAB

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murAB

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