Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
MurM (407 amino acids) and MurN (411 amino acids), involved with the addition of the first and second amino acid residues, respectively, to the cell wall precursor stem peptide at the lipid II stage of biosynthesis
Overview
The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae.
The murMN operon plays a key role in the regulation of a stress-response pathway that can be triggered by perturbation of cell wall biosynthesis in Streptococcus pneumoniae, affecting both antibiotic resistance and tolerance.
Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.
The study identifies numerous genes and mutations associated with antibiotic resistance in Streptococcus pneumoniae through genome-wide association studies, highlighting the genetic basis of resistance to penicillin, trimethoprim, cotrimoxazole, erythromycin, and fluoroquinolones.
Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane.
The study identifies MurM as a penicillin resistance determinant in Streptococcus pneumoniae, revealing its role in modifying Lipid II and influencing peptidoglycan crosslinking. Structural and computational analyses demonstrate that MurM's activity is modulated by membrane phospholipids, particularly cardiolipin, which enhances its enzymatic activity.
The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci.
The study identifies pbp2x, pbp2b, pbp1a, and murM as the main resistance determinants for amoxicillin resistance in Streptococcus pneumoniae, demonstrating that the order of allele uptake is important for successful resistance evolution.
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