Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
uridylyl transferase
Overview
Blocking peptidoglycan recycling in Pseudomonas aeruginosa attenuates intrinsic resistance to fosfomycin.
The study identifies amgK, murU, and anmK as genes involved in peptidoglycan recycling that contribute to intrinsic fosfomycin resistance in Pseudomonas aeruginosa. Deletion of these genes significantly increases fosfomycin susceptibility.
Synergism of imipenem with fosfomycin associated with the active cell wall recycling and heteroresistance in Acinetobacter calcoaceticus-baumannii complex.
The study identifies carbapenemase genes blaOXA-24, blaOXA-23, and blaOXA-58 along with blaIMP in various Acinetobacter isolates, contributing to carbapenem resistance. It also highlights the role of cell wall recycling pathways and heteroresistance in modulating the effectiveness of imipenem-fosfomycin synergy.
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