mutH

DNA mismatch repair endonuclease

Overview

Mechanism: disrupts catalysis due to loss of this stabilizing hydrophobic interaction
Drug Classes: ceftazidime avibactam|meropenem vaborbactam
Organisms: Klebsiella pneumoniae
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V76G	G227A	disrupts catalysis due to loss of this stabilizing hydrophobic interaction	Klebsiella pneumoniae	ceftazidime avibactam\|meropenem vaborbactam	Reslit	Candidate

Papers1

Emergence of mutH (V76G) among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype.

PMID 41332554 · 2025

The V76G substitution in mutH leads to a hypermutator phenotype, resulting in increased resistance to ceftazidime-avibactam and meropenem-vaborbactam.

Mutation Information

mutH: p.V76G / c.G227A

Protein Change: V76G
Nucleotide Change: G227A
Organisms: Klebsiella pneumoniae
Confers Resistance To: ceftazidime avibactam|meropenem vaborbactam
Effect on Function: disrupts catalysis due to loss of this stabilizing hydrophobic interaction
Validation Method: whole genome sequencing and functional assays
Source Database: Reslit

mutH

Mutations

Mutation Information

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mutH

Mutations

Mutation Information