mutM

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DNA repair enzyme

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to mutM

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Validation StatusSupported

Overview

Mechanism: inactivation leads to increased mutation frequency and antibiotic resistance
Validation Method: mutation frequency measurement and antibiotic susceptibility testing
Drug Classes: rifampicin, streptomycin, ciprofloxacin, levofloxacin, fluoroquinolones
Organisms: Pseudomonas aeruginosa, Escherichia coli, Pseudomonas aeruginosa PAS71, Pseudomonas aeruginosa PAS81, E. coli
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A422S	-	-	E. coli	ciprofloxacinfluoroquinolones	Reslit	Candidate

Papers3

Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.

PMID 19332676 · 2009

Inactivation of the DNA oxidative repair system genes mutT, mutY, and mutM in Pseudomonas aeruginosa leads to increased mutation frequency and antibiotic resistance, primarily through increased β-lactamase production and overexpression of the MexCD-OprJ efflux pump.

Gene Information

Gene Name: mutM
Allele: mutM
Encodes: DNA repair enzyme
Source Database: Reslit
Mechanism: inactivation leads to increased mutation frequency and antibiotic resistance
Confers Resistance To: rifampicinstreptomycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: mutation frequency measurement and antibiotic susceptibility testing

Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates.

PMID 23824211 · 2013

The study identifies novel SNPs in gyrA, mutM, ligB, and recG genes associated with fluoroquinolone resistance in E. coli clinical isolates, demonstrating their role in resistance mechanisms through experimental validation.

Gene Information

Gene Name: mutM
Allele: mutM
Encodes: 8-oxoguanine DNA glycosylase
Source Database: Reslit
Mechanism: non-synonymous mutation leading to fluoroquinolone resistance
Confers Resistance To: ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: plasmid complementation and MIC testing
Sequence Accession: CP000948.1|CP000819.1|CP000970.1|NC_010488.1

Pseudomonas aeruginosa heteroresistance to levofloxacin caused by upregulated expression of essential genes for DNA replication and repair.

PMID 36620018 · 2022

The study identifies that upregulated expression of genes involved in DNA replication and repair, such as recA, uvrD, xseB, ssb, mutM, and crc, contributes to levofloxacin heteroresistance in Pseudomonas aeruginosa strains PAS71 and PAS81. Additionally, the expression of genes related to bacterial secretion systems, such as gspD, vgrG1, hcpC, clpV1, and ppkA, is increased in PAS81 under LVX stress.

Gene Information

Gene Name: mutM
Allele: mutM
Encodes: bifunctional glycosylase Fpg
Source Database: Reslit
Mechanism: upregulated expression enhances DNA repair
Confers Resistance To: levofloxacin
Organisms Tested In: • Pseudomonas aeruginosa PAS71
• Pseudomonas aeruginosa PAS81
Validation Method: transcriptomic analysis and qRT-PCR
Sequence Accession: PRJNA781681|PRJNA891088|GSE217409|GSE189021

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

A422S

E. coli

ciprofloxacinfluoroquinolones

Reslit

Candidate

mutM

Mutations

Gene Information

Gene Information

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mutM

Mutations

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