mutT

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DNA repair enzyme

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mutT

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: inactivation leads to increased mutation frequency and antibiotic resistance
Validation Method: mutation frequency measurement and antibiotic susceptibility testing
Drug Classes: rifampicin, streptomycin
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.

PMID 19332676 · 2009

Inactivation of the DNA oxidative repair system genes mutT, mutY, and mutM in Pseudomonas aeruginosa leads to increased mutation frequency and antibiotic resistance, primarily through increased β-lactamase production and overexpression of the MexCD-OprJ efflux pump.

Gene Information

Gene Name: mutT
Allele: mutT
Encodes: DNA repair enzyme
Source Database: Reslit
Mechanism: inactivation leads to increased mutation frequency and antibiotic resistance
Confers Resistance To: rifampicinstreptomycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: mutation frequency measurement and antibiotic susceptibility testing

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mutT

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mutT

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