Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
enzyme involved in cell wall recycling
Overview
Synergism of imipenem with fosfomycin associated with the active cell wall recycling and heteroresistance in Acinetobacter calcoaceticus-baumannii complex.
The study identifies carbapenemase genes blaOXA-24, blaOXA-23, and blaOXA-58 along with blaIMP in various Acinetobacter isolates, contributing to carbapenem resistance. It also highlights the role of cell wall recycling pathways and heteroresistance in modulating the effectiveness of imipenem-fosfomycin synergy.
An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa.
The study shows that targeting nagZ with a PPNA reduces AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa, demonstrating the potential of antisense strategies to restore antibiotic susceptibility.
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