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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
new factor required for maturing Fe/S proteins
Overview
Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis.
The study shows that the SUF machinery is required for E. coli to resist PMS stress and that SoxR maturation under PMS stress is primarily mediated by the SUF system. Additionally, the study identifies the role of the AcrAB efflux pump in PMS-mediated protection against fluoroquinolones.
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