Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
nitroimidazole reductase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| nimA | Card DatabaseResFinder Database | 2 | METRONIDAZOLE | Phocaeicola vulgatus | - | 1994 | X71444.1 | CAA50581.1 |
| NimA | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | metronidazole, METRONIDAZOLE +1 | Bacteroides fragilis +5 | Europe, Denmark, Netherlands | 1994, 2005, 2007, 2014, 2019, 2022, 2024 | AJ515145 | CAA50581.1 |
| nim | Reslit | 3 | metronidazole | Prevotella sp. +2 | China | 2005, 2020 | AY957555|AY957556 | - |
Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
The study identifies nim genes, including a novel nimF, as mediators of inducible metronidazole resistance in Bacteroides fragilis group isolates, highlighting the clinical significance of these genes in resistance development.
Bacteremia caused by a metronidazole-resistant Prevotella sp. strain.
The study reports the first case of bacteremia caused by a metronidazole-resistant Prevotella sp. strain, highlighting the presence of nim genes associated with metronidazole resistance.
Inducible Metronidazole Resistance in nim–Positive and nim–Negative Bacteroides fragilis Group Strains after Several Passages Metronidazole Containing Columbia Agar Plates
The study shows that metronidazole resistance can develop in both nim-positive and nim-negative Bacteroides fragilis group strains, indicating the involvement of mechanisms beyond nim genes.
Bacteroides: the good, the bad, and the nitty-gritty.
The review discusses the role of Bacteroides species as commensals and pathogens, highlighting their complex relationships with the host, their resistance mechanisms, and their impact on health and disease.
A study on Nim expression in Bacteroides fragilis.
The study demonstrates that NimA, NimB, NimD, and NimE are expressed at the protein level in Bacteroides fragilis and are associated with metronidazole resistance, though no clear correlation between Nim protein levels and resistance levels was observed.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Higher Prevalence of Multi-Antimicrobial Resistant Bacteroides spp. Strains Isolated at a Tertiary Teaching Hospital in China.
The study identifies the cfiA gene as the primary mechanism of carbapenem resistance in Bacteroides fragilis, along with other resistance genes such as cfxA, cepA, ermF, and nim. These genes contribute to resistance against various antibiotics including carbapenems, cefoxitin, clindamycin, and metronidazole.
Modulation of Iron Import and Metronidazole Resistance in Bacteroides fragilis Harboring a nimA Gene.
The study identifies the nimA gene as a determinant of metronidazole resistance in Bacteroides fragilis, showing that it modulates iron import and preserves PFOR and TrxR activities, thereby enhancing oxygen tolerance.
Antimicrobial susceptibility profile of clinically relevant Bacteroides, Phocaeicola, Parabacteroides and Prevotella species, isolated by eight laboratories in the Netherlands.
The study identified cfiA, nimE, and nimA genes as responsible for carbapenem and metronidazole resistance in various Bacteroides, Phocaeicola, and Prevotella species.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
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