Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
nitroimidazole reductase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Y130S | - | confers resistance | Clostridioides difficile | metronidazole | Reslit | Candidate |
| L155I | - | confers resistance | Clostridioides difficile | metronidazole | Reslit | Candidate |
| - | constitutive expression of nimB, resulting in metronidazole resistance | Clostridioides difficile | metronidazole | Reslit | Candidate | |
| - | - | Clostridioides difficile | metronidazole | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| nimB | Card DatabaseResFinder Database | 2 | METRONIDAZOLE | Bacteroides fragilis | - | 1994 | X71443.1 | CAA50578.1 |
| NimB | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | metronidazole, tetracycline +2 | Bacteroides fragilis +5 | Europe, Saudi Arabia, US|Europe|United States|Israel, Poland, China | 1994, 2005, 2014, 2022, 2023, 2025, 2026 | AJ515145 | CAA50578.1 |
Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
The study identifies nim genes, including a novel nimF, as mediators of inducible metronidazole resistance in Bacteroides fragilis group isolates, highlighting the clinical significance of these genes in resistance development.
A study on Nim expression in Bacteroides fragilis.
The study demonstrates that NimA, NimB, NimD, and NimE are expressed at the protein level in Bacteroides fragilis and are associated with metronidazole resistance, though no clear correlation between Nim protein levels and resistance levels was observed.
Paraphocaeicola brunensis gen. nov., sp. nov., Carrying Two Variants of nimB Resistance Gene from Bacteroides fragilis, and Caecibacteroides pullorum gen. nov., sp. nov., Two Novel Genera Isolated from Chicken Caeca.
The study identifies two novel genera, Paraphocaeicola brunensis and Caecibacteroides pullorum, isolated from chicken caeca. It reports the presence of the nimB resistance gene in Paraphocaeicola brunensis, which confers resistance to metronidazole.
Genomic Insights into Virulence Factors and Multi-Drug Resistance in Clostridium perfringens IRMC2505A.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant Clostridium perfringens IRMC2505A strain, including NimB, TetB(P), fabV, TetA(P), gidB, FabK-like, and mprF, which confer resistance to tetracycline and defensin-like cationic antimicrobial peptides.
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.
The study identifies nimB as a heme-dependent 5-nitroimidazole reductase that confers metronidazole resistance in Clostridioides difficile. A T-to-G mutation in the promoter region of nimB leads to constitutive expression, resulting in resistance. This mutation is associated with fluoroquinolone resistance due to a Thr82Ile substitution in GyrA.
Newly emerging metronidazole-resistant Clostridioides difficile PCR ribotype 955 identified in Poland, 2021 to 2023 but not in Czechia, 2012 to 2023 and Slovakia, 2015 to 2023.
The study identified metronidazole-resistant Clostridioides difficile PCR ribotype 955 in Poland, with resistance mechanisms involving mutations in the nimB gene and its promoter.
Reversion of heme-dependent metronidazole resistance in Clostridioides difficile.
Artemisinin (ART) was identified as an adjuvant capable of resensitizing heme-dependent metronidazole (MTZ) non-susceptible Clostridioides difficile and Bacteroides fragilis by reducing intracellular hemin levels and reversing nimB-mediated resistance.
A severe Clostridioides difficile ribotype 027 infection in Beijing, China, july 2024.
The study identified vancomycin resistance mediated by a mutation in the VanR gene and metronidazole resistance associated with the nimB gene in a Clostridioides difficile ribotype 027 isolate.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
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