Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
5-nitroimidazole reductase NimE
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| NimE | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | METRONIDAZOLE, NITROIMIDAZOLE +2 | Bacteroides fragilis +5 | Europe, Denmark, Canada, India, Bangladesh, Netherlands | 2005, 2014, 2019, 2020, 2021, 2022, 2023, 2024 | CP036548.1 | QCQ47774.1 |
| nimE | Card DatabaseResFinder Database | 2 | METRONIDAZOLE | Bacteroides fragilis | - | 2000 | CP036548.1 | QCQ47774.1 |
PCR-restriction fragment length polymorphism analysis for identification of Bacteroides spp. and characterization of nitroimidazole resistance genes., Molecular investigation of genetic elements contributing to metronidazole resistance in Bacteroides strains.
Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
The study identifies nim genes, including a novel nimF, as mediators of inducible metronidazole resistance in Bacteroides fragilis group isolates, highlighting the clinical significance of these genes in resistance development.
A study on Nim expression in Bacteroides fragilis.
The study demonstrates that NimA, NimB, NimD, and NimE are expressed at the protein level in Bacteroides fragilis and are associated with metronidazole resistance, though no clear correlation between Nim protein levels and resistance levels was observed.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Identification and characterization of invasive multi-drug-resistant (MDR) Bacteroides genomospecies in Canada.
The study identifies a novel multidrug-resistant Bacteroides genomospecies carrying the nimE gene associated with metronidazole resistance, along with other resistance genes such as tetQ, cfiA13, and erm(F).
Phenotypic and genotypic antimicrobial resistance in clinical anaerobic isolates from India.
The study identified the nimE gene associated with metronidazole resistance in Bacteroides fragilis and the cfiA gene linked to imipenem resistance in Bacteroides spp.
Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children.
The study identified several antibiotic resistance genes (ARGs) in the gut microbiome of Bangladeshi children, including bla CTX-M, mph(A), qnrS1, mdf(A), tet(A), sul2, aadA5, tet(X), erm(X), nimE, dfrA17, bla TEM, and ant(6’)-Ia. These genes were associated with resistance to various antibiotics such as third-generation cephalosporins, azithromycin, fluoroquinolones, tetracyclines, sulfonamides, streptomycin, spectinomycin, macrolides, lincosamides, streptogramin B, nitroimidazoles, trimethoprim, penicillins, and aminoglycosides.
Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.
The study identifies several AMR genes in anaerobic Gram-negative bacteria, including nimE for metronidazole resistance, ermF for clindamycin resistance, cfiA for imipenem resistance, cepA for piperacillin-tazobactam resistance, and cfxA for cefoxitin resistance.
Antimicrobial susceptibility profile of clinically relevant Bacteroides, Phocaeicola, Parabacteroides and Prevotella species, isolated by eight laboratories in the Netherlands.
The study identified cfiA, nimE, and nimA genes as responsible for carbapenem and metronidazole resistance in various Bacteroides, Phocaeicola, and Prevotella species.
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