nimJ

nitroimidazole reductase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in B. fragilis 638R and MIC testing
Drug Classes: metronidazole, METRONIDAZOLE, NITROIMIDAZOLE
Organisms: Bacteroides fragilis, Bacteroides fragilis HMW 615
Geographic Location: Denmark, United States|South Africa
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
nimJ	Card DatabaseResFinder Database	2	METRONIDAZOLE	Bacteroides fragilis +1	-	-	KJ816753.1	AIM40056.1
NimJ	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	metronidazole, METRONIDAZOLE +1	Bacteroides fragilis	United States\|South Africa, Denmark	2013, 2014, 2019	HMPREF1204_00002\|HMPREF1204_02912\|HMPREF1204_04081\|HMPREF1205_01450\|HMPREF1203_04663	AIM40056.1

Papers4

PMID N/A

Gene Information

Gene Name: nimJ
Allele: nimJ
Encodes: nitroimidazole reductase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Bacteroides fragilis
Sequence Accession: KJ816753.1
Protein Accession: AIM40056.1
Notes: ARO:3007112

Two multidrug-resistant clinical isolates of Bacteroides fragilis carry a novel metronidazole resistance nim gene (nimJ).

PMID 23716049 · 2013

The study identifies a novel metronidazole resistance gene, nimJ, in multidrug-resistant Bacteroides fragilis clinical isolates. This gene was shown to increase metronidazole resistance when introduced into a susceptible strain.

Gene Information

Gene Name: nimJ
Allele: NimJ
Encodes: nitroimidazole reductase
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Bacteroides fragilis
Geographic Location: United States|South Africa
Validation Method: cloning in B. fragilis 638R and MIC testing
Sequence Accession: HMPREF1204_00002|HMPREF1204_02912|HMPREF1204_04081|HMPREF1205_01450|HMPREF1203_04663

The Ellis Island Effect: A novel mobile element in a multi-drug resistant Bacteroides fragilis clinical isolate includes a mosaic of resistance genes from Gram-positive bacteria.

PMID 25165618 · 2014

Gene Information

Gene Name: nimJ
Allele: NimJ
Encodes: 5-nitroimidazole reductase NimJ
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: METRONIDAZOLENITROIMIDAZOLE
Organisms Tested In: • Bacteroides fragilis
Sequence Accession: KJ816753.1
Protein Accession: AIM40056.1
Notes: Manually predicted - likely also resistance to tinidazole, nimorazole, dimetridazole, 6-Amino PA824, ornidazole, megazol, azanidazole

The Ellis Island Effect: A novel mobile element in a multi-drug resistant Bacteroides fragilis clinical isolate includes a mosaic of resistance genes from Gram-positive bacteria.

PMID 25165618 · 2014

Gene Information

Gene Name: nimJ
Allele: NimJ
Encodes: 5-nitroimidazole reductase NimJ
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: METRONIDAZOLENITROIMIDAZOLE
Organisms Tested In: • Bacteroides fragilis
Sequence Accession: KJ816753.1
Protein Accession: AIM40056.1
Notes: Manually predicted - likely also resistance to tinidazole, nimorazole, dimetridazole, 6-Amino PA824, ornidazole, megazol, azanidazole

The Ellis Island Effect: A novel mobile element in a multi-drug resistant Bacteroides fragilis clinical isolate includes a mosaic of resistance genes from Gram-positive bacteria.

PMID 25165618 · 2014

Gene Information

Gene Name: nimJ
Allele: NimJ
Encodes: 5-nitroimidazole reductase NimJ
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: METRONIDAZOLENITROIMIDAZOLE
Organisms Tested In: • Bacteroides fragilis
Sequence Accession: KJ816753.1
Protein Accession: AIM40056.1
Notes: Manually predicted - likely also resistance to tinidazole, nimorazole, dimetridazole, 6-Amino PA824, ornidazole, megazol, azanidazole

Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.

PMID 31697231 · 2019

The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.

Gene Information

Gene Name: nimJ
Allele: NimJ
Encodes: nitroimidazole reductase
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Bacteroides fragilis
Geographic Location: Denmark
Validation Method: ABRicate screening with ResFinder, NCBI, and CARD databases
Sequence Accession: PRJNA525024|PRJNA244942|PRJNA244943|PRJNA244944|PRJNA253771|PRJNA254401|PRJNA254455

PMID unpublished

Gene Information

Gene Name: nimJ
Allele: nimJ
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: METRONIDAZOLE
Organisms Tested In: • Bacteroides fragilis HMW 615
Sequence Accession: JH815495
Notes: Manually predicted - likely also resistance to tinidazole, nimorazole, dimetridazole, 6-Amino PA824, ornidazole, megazol, azanidazole

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Allele

Database

Papers

Drug Classes

Organisms

Countries

Years

Sequence Accession

Protein Accession

nimJ

Card DatabaseResFinder Database

METRONIDAZOLE

Bacteroides fragilis +1

KJ816753.1

AIM40056.1

NimJ

Card DatabaseReference Gene CatalogResFinder DatabaseReslit

metronidazole, METRONIDAZOLE +1

Bacteroides fragilis

United States|South Africa, Denmark

2013, 2014, 2019

HMPREF1204_00002|HMPREF1204_02912|HMPREF1204_04081|HMPREF1205_01450|HMPREF1203_04663

AIM40056.1

nimJ

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