nlpD

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activator of AmiC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nlpD

AMR Rules

Browse AMR rules for nlpD

Validation StatusCandidate

Overview

Validation Method: knock-in approach
Drug Classes: imipenem, ampicillin
Organisms: Escherichia coli, Klebsiella pneumoniae
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	C187T	-	Escherichia coli	ampicillin	Reslit	Candidate
-	C481T	-	-	imipenem	Reslit	Candidate

Papers2

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

PMID 31744905 · 2019

The study identified several genes and mutations associated with imipenem resistance in Gram-negative bacteria, including rpoD, amiC, nlpD, wecA, slt, and oprD, through mutagenesis and functional validation experiments.

Gene Information

Gene Name: nlpD
Allele: nlpD
Encodes: activator of AmiC
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Validation Method: knock-in approach
Sequence Accession: PRJNA244551|PRJNA244567|PRJNA316664

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nlpD

Mutations

Gene Information

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nlpD

Mutations

Gene Information