nms

multidrug efflux MFS transporter Nms

Validation StatusConfirmed2+ DBs

Overview

Mechanism: efflux pump
Validation Method: efflux activity assays, antimicrobial susceptibility testing
Drug Classes: MINOCYCLINE, TETRACYCLINE, DOXYCYCLINE, PLEUROMUTILIN, CLINDAMYCIN, AMIKACIN, ERYTHROMYCIN, GENTAMICIN, macrolides, lincosamides, aminoglycosides, tetracycline, pleuromutilins
Organisms: Staphylococcus aureus, Staphylococcus epidermidis
Geographic Location: China|South Korea|Brazil
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Gene Information

Gene Name: nms
Allele: nms
Encodes: multidrug efflux MFS transporter Nms
Source Database: Reference Gene Catalog
Confers Resistance To: MINOCYCLINETETRACYCLINEDOXYCYCLINEPLEUROMUTILINCLINDAMYCINAMIKACINERYTHROMYCINGENTAMICIN
Organisms Tested In: • Staphylococcus aureus
Sequence Accession: JAKKVD010000039.1
Protein Accession: MCQ9895171.1

Identification and characterization of a novel major facilitator superfamily (MFS) efflux pump conferring multidrug resistance in Staphylococcus aureus and Staphylococcus epidermidis.

PMID 40192467 · 2025

The study identifies a novel MFS efflux pump, Nms, which confers multidrug resistance in Staphylococcus aureus and Staphylococcus epidermidis. The nms gene is prevalent in S. aureus ST398 and ST541 strains and is associated with plasmid-mediated transmission.

Gene Information

Gene Name: nms
Allele: nms
Encodes: transporter protein
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: macrolideslincosamidesaminoglycosidestetracyclinepleuromutilins
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus epidermidis
Geographic Location: China|South Korea|Brazil
Validation Method: efflux activity assays, antimicrobial susceptibility testing
Sequence Accession: GCA_004011165.1|GCA_013372685.1

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nms

multidrug efflux MFS transporter Nms

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nms

AMR Rules

Browse AMR rules for nms

Validation StatusConfirmed2+ DBs

Overview

Mechanism: efflux pump
Validation Method: efflux activity assays, antimicrobial susceptibility testing
Drug Classes: MINOCYCLINE, TETRACYCLINE, DOXYCYCLINE, PLEUROMUTILIN, CLINDAMYCIN, AMIKACIN, ERYTHROMYCIN, GENTAMICIN, macrolides, lincosamides, aminoglycosides, tetracycline, pleuromutilins
Organisms: Staphylococcus aureus, Staphylococcus epidermidis
Geographic Location: China|South Korea|Brazil
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: nms
Allele: nms
Encodes: multidrug efflux MFS transporter Nms
Source Database: Reference Gene Catalog
Confers Resistance To: MINOCYCLINETETRACYCLINEDOXYCYCLINEPLEUROMUTILINCLINDAMYCINAMIKACINERYTHROMYCINGENTAMICIN
Organisms Tested In: • Staphylococcus aureus
Sequence Accession: JAKKVD010000039.1
Protein Accession: MCQ9895171.1

Identification and characterization of a novel major facilitator superfamily (MFS) efflux pump conferring multidrug resistance in Staphylococcus aureus and Staphylococcus epidermidis.

PMID 40192467 · 2025

Gene Information

Gene Name: nms
Allele: nms
Encodes: transporter protein
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: macrolideslincosamidesaminoglycosidestetracyclinepleuromutilins
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus epidermidis
Geographic Location: China|South Korea|Brazil
Validation Method: efflux activity assays, antimicrobial susceptibility testing
Sequence Accession: GCA_004011165.1|GCA_013372685.1

Comments (0)

No comments yet. Be the first to comment!

nms

Gene Information

Gene Information

Browse AMR Genes

nms

Gene Information

Gene Information