Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major facilitator superfamily (MFS) antibiotic efflux pump
Overview
MgrA Is a Multiple Regulator of Two New Efflux Pumps in Staphylococcus aureus
The study identifies two novel efflux pumps, NorB and Tet38, in Staphylococcus aureus, which confer resistance to quinolones and tetracycline, respectively. MgrA negatively regulates the expression of these pumps.
Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.
The study identifies several efflux pump genes (mepA, mdeA, norA, norB, norC) that are overexpressed in bloodstream isolates of Staphylococcus aureus, contributing to resistance against norfloxacin, biocides, and dyes.
Ethidium bromide MIC screening for enhanced efflux pump gene expression or efflux activity in Staphylococcus aureus.
The study identifies norA, norB, mepA, qacA, and qacB as efflux pump genes contributing to antimicrobial resistance in Staphylococcus aureus through increased expression and efflux activity.
Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin.
The study shows that the NorB efflux pump contributes to resistance to moxifloxacin in Staphylococcus aureus, particularly under acidic pH conditions.
Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA.
Reduced aeration increases the expression of the NorB efflux pump in Staphylococcus aureus, leading to increased resistance to moxifloxacin and sparfloxacin.
Association of norB overexpression and fluoroquinolone resistance in clinical isolates of Staphylococcus aureus from Korea.
Overexpression of the norB gene is associated with increased fluoroquinolone resistance in clinical isolates of Staphylococcus aureus, particularly in methicillin-resistant strains.
Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria.
The paper discusses the role of multidrug efflux pumps in microaerobic and anaerobic bacteria, highlighting their importance in antibiotic resistance. Several efflux systems were identified and characterized, including CmeABC, CmeDEF, CmeG, NhaA1/NhaA2, HefABC, HefDEF, HefGHI, NorB, BmeABC1-16, BexA, MdtEF, CusCBA, AcrAB, TolC, TetA, XepCAB, and bcRABD, each contributing to resistance against various antibiotics.
Eradication and Sensitization of Methicillin Resistant Staphylococcus aureus to Methicillin with Bioactive Extracts of Berry Pomace.
The study shows that bioactive extracts of berry pomace can sensitize methicillin-resistant Staphylococcus aureus (MRSA) to methicillin by down-regulating the expression of methicillin resistance genes (mecA) and efflux pump genes (norA, norB, norC, mdeA, sdrM, sepA).
Increased Usage of Antiseptics Is Associated with Reduced Susceptibility in Clinical Isolates of Staphylococcus aureus.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
Prevalence and Population Diversity of Listeria monocytogenes Isolated from Dairy Cattle Farms in the Cantabria Region of Spain.
The study identified four antimicrobial resistance genes (fosX, lin, norB, and mprF) in 45 L. monocytogenes isolates, with resistance to various antibiotics including fosfomycin, lincomycin, quinolones, and cationic peptides. No significant differences in resistance ratios were found between organic and conventional farms.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Antibiotics Resistance and Adhesive Properties of Clinical Staphylococcus aureus Isolated from Wound Infections.
The study identified the presence of antibiotic resistance genes blaZ, mecA, norA, and norB in clinical Staphylococcus aureus isolates from wound infections, highlighting their role in resistance to beta-lactams, methicillin, fluoroquinolones, and nitrofurantoin.
Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.
The study identifies mutations in grlA (S80F) and gyrB (T451S and/or R450S) as key contributors to fluoroquinolone resistance in Staphylococcus aureus, along with overexpression of rimI and fmtB.
Genomic Insights into Listeria monocytogenes: Organic Acid Interventions for Biofilm Prevention and Control.
The study identified several antimicrobial resistance genes in Listeria monocytogenes, including Cat, Ide, mrsA, lin, fosX, mprF, vgaL, sul, norB, GyrA, GyrB, ParC, ParEm, FepR, and radC, which confer resistance to various antibiotics such as chloramphenicol, macrolides, lincosamides, streptogramins, phosphonic acids, peptides, fluoroquinolones, and sulfonamides.
Multidrug Efflux System-mediated resistance in Staphylococcus aureus under a One Health approach.
The study identifies several multidrug efflux system genes (norA, norB, norC, lmrS, tet38, msrA) in Staphylococcus aureus isolates from human, animal, and food sources, highlighting their role in resistance to various antibiotics.
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
Molecular Characterization and Antimicrobial Resistance Evaluation of Listeria monocytogenes Strains from Food and Human Samples.
The study identified several intrinsic antimicrobial resistance genes in Listeria monocytogenes strains, including fosX, norB, sul, and lmo0919, which confer resistance to fosfomycin, quinolones, sulfonamides, and lincosamides, respectively.
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