npmB

16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB1

Validation StatusConfirmed2+ DBs

Overview

Mechanism: posttranslational methylation of the A site of 16S rRNA at position A1408
Validation Method: generation of NpmB1-producing E. coli JM109(DE3) laboratory strain, susceptibility testing, primer extension assay, ELISA
Drug Classes: AMINOGLYCOSIDE, aminoglycosides
Organisms: Escherichia coli
Geographic Location: United Kingdom
Alleles: 2
Papers: 1
Databases: Reference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
NpmB1	Reference Gene CatalogReslit	2	AMINOGLYCOSIDE, aminoglycosides	Escherichia coli	United Kingdom	2021	AAVRUE010000189.1	EGD5494512.1
NpmB2	Reference Gene Catalog	1	AMINOGLYCOSIDE	Escherichia coli	-	-	AAAGDO010000044.1	EAB8931753.1

Papers1

PMID N/A

Gene Information

Gene Name: npmB
Allele: NpmB1
Encodes: 16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB1
Source Database: Reference Gene Catalog
Confers Resistance To: AMINOGLYCOSIDE
Organisms Tested In: • Escherichia coli
Sequence Accession: AAVRUE010000189.1
Protein Accession: EGD5494512.1

PMID N/A

Gene Information

Gene Name: npmB
Allele: NpmB2
Encodes: 16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB2
Source Database: Reference Gene Catalog
Confers Resistance To: AMINOGLYCOSIDE
Organisms Tested In: • Escherichia coli
Sequence Accession: AAAGDO010000044.1
Protein Accession: EAB8931753.1

Functional and Structural Characterization of Acquired 16S rRNA Methyltransferase NpmB1 Conferring Pan-Aminoglycoside Resistance.

PMID 34310216 · 2021

NpmB1 is a newly identified acquired 16S rRNA methyltransferase that confers pan-aminoglycoside resistance by methylating the N1 position of A1408 of 16S rRNA in vivo.

Gene Information

Gene Name: npmB
Allele: NpmB1
Encodes: 16S rRNA methyltransferase
Source Database: Reslit
Mechanism: posttranslational methylation of the A site of 16S rRNA at position A1408
Confers Resistance To: aminoglycosides
Organisms Tested In: • Escherichia coli
Geographic Location: United Kingdom
Validation Method: generation of NpmB1-producing E. coli JM109(DE3) laboratory strain, susceptibility testing, primer extension assay, ELISA
Sequence Accession: EGD5494512.1|MJZ53392.1|EAB8931753.1|EAB9582428.1

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Allele

Database

Papers

Drug Classes

Organisms

Countries

Years

Sequence Accession

Protein Accession

NpmB1

Reference Gene CatalogReslit

AMINOGLYCOSIDE, aminoglycosides

Escherichia coli

United Kingdom

2021

AAVRUE010000189.1

EGD5494512.1

NpmB2

Reference Gene Catalog

AMINOGLYCOSIDE

Escherichia coli

AAAGDO010000044.1

EAB8931753.1

npmB

Gene Information

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