npma2

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16S rRNA methyltransferase

NCBI Pathogen Isolates

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UniProt

Protein entries specific to npma2

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Validation StatusCandidate

Overview

Validation Method: genomic characterization and phenotypic analysis
Drug Classes: aminoglycosides
Organisms: Clostridioides difficile, Enterococcus faecium
Geographic Location: UK|Germany|USA|Australia|China|France|global
Papers: 1
Databases: Reslit

Papers1

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria.

PMID 40675954 · 2025

The study identifies the npmA2 gene as a key mediator of pan-aminoglycoside resistance in Gram-positive bacteria, particularly in Clostridioides difficile and Enterococcus faecium, through a mobile genetic element (Tn 7734 and ICE Tn 7740).

Gene Information

Gene Name: npma2
Allele: npmA2
Encodes: 16S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Clostridioides difficile
• Enterococcus faecium
Geographic Location: UK|Germany|USA|Australia|China|France|global
Validation Method: genomic characterization and phenotypic analysis
Sequence Accession: AB261016.2|FN665653.1|CP038996.1|NG_048018.1|NZ_JFOF01000002.1

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npma2

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npma2

Gene Information