nsrR

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transcriptional regulator

NCBI Pathogen Isolates

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Validation StatusCandidate

Overview

Mechanism: regulation of oxidative stress response
Validation Method: genetic deletion and complementation
Drug Classes: tetracycline
Organisms: Klebsiella pneumoniae
Papers: 1
Databases: Reslit

Papers1

Evolution of triclosan resistance modulates bacterial permissiveness to multidrug resistance plasmids and phages.

PMID 38688912 · 2024

The study shows that triclosan resistance in K. pneumoniae leads to cross-resistance to clinical antibiotics and increased permissiveness to multidrug resistance plasmids and phages. Key genes identified include fabI, mgrB, fosA5, and oqxB19-like, along with mutations in nsrR and ndh.

Gene Information

Gene Name: nsrR
Allele: nsrR
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: regulation of oxidative stress response
Confers Resistance To: tetracycline
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genetic deletion and complementation
Sequence Accession: PRJNA937637|SAMN33774534|SAMN33604226

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nsrR

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nsrR

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