nudB

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enzyme involved in folate biosynthesis

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UniProt

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Validation StatusCandidate

Overview

Mechanism: increases flux through folate biosynthesis pathway
Validation Method: overexpression in E. coli and resistance measurement
Drug Classes: trimethoprim
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance.

PMID 30169679 · 2018

The study identifies numerous genes whose expression changes can confer resistance to various antibiotics, highlighting the role of nonoptimal gene expression in antibiotic resistance development.

Gene Information

Gene Name: nudB
Allele: nudB
Encodes: enzyme involved in folate biosynthesis
Source Database: Reslit
Mechanism: increases flux through folate biosynthesis pathway
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: overexpression in E. coli and resistance measurement

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nudB

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nudB

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