Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ethionamide resistant nudC
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P226Q | - | disruption of dimerization and enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| D133A | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| N148D | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| F156A | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| F193A | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| E207Q | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| E211Q | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| R231Q | - | loss of enzymatic activity | Mycobacterium abscessus | isoniazid|ethionamide | Reslit | Candidate |
| S287N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A216fs | - | frameshift mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| P239R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Mtub_nudC_ETO | Card Database | 1 | - | Mycobacterium tuberculosis H37Rv | - | - | NC_000962.3 | NP_217715.1 |
| nudC | Reslit | 3 | isoniazid, ethionamide | Mycobacterium smegmatis mc 2 155 +4 | Europe|Asia|Central Asia|Germany | 2011, 2020, 2026 | NCBI:PRJNA610123|NZ_HG813240.1|NC_020089.1 | - |
Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivation.
The study identifies NudC as a novel mechanism for isoniazid and ethionamide inactivation in mycobacteria, demonstrating that overexpression of NudC leads to resistance against these drugs, while its inactivation increases susceptibility.
Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.
Indels in Mycobacterium tuberculosis are significantly enriched in antibiotic resistance genes, contributing to the evolution of multidrug resistance in an outbreak. Specific genes like pncA, mmaA3, ethA, espK, and nudC were identified as being disrupted by indels, leading to resistance against pyrazinamide, isoniazid, and ethionamide.
The MAB_3513c gene plays a key role in intrinsic resistance of Mycobacterium abscessus to isoniazid and ethionamide.
The study identifies the MAB_3513c gene, encoding NudC, as a key determinant of intrinsic resistance to isoniazid and ethionamide in Mycobacterium abscessus. Mutations in NudC, particularly P226Q, significantly reduce resistance.
No comments yet. Be the first to comment!