nuoA

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NADH dehydrogenase subunit

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nuoA

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Validation StatusCandidate

Overview

Mechanism: 29358649
Validation Method: transposon insertion library and genetic footprinting
Drug Classes: tobramycin
Organisms: Pseudomonas aeruginosa, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G-314T	29358649	Mycobacterium tuberculosis	-	ResFinder Database	Candidate

Papers1

Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms.

PMID 22028649 · 2011

The study identifies several genes, including nuoK, nuoA, wzm, PA3726, and PA0614, that contribute to tobramycin tolerance in Pseudomonas aeruginosa biofilms. These genes are associated with oxidative phosphorylation, membrane permeability, and other mechanisms that enhance antibiotic tolerance.

Gene Information

Gene Name: nuoA
Allele: nuoA
Encodes: NADH dehydrogenase subunit
Source Database: Reslit
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: transposon insertion library and genetic footprinting
Sequence Accession: GSE26142

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nuoA

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nuoA

Mutations

Gene Information