nuoD

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NADH-quinone oxidoreductase subunit C/D

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nuoD

AMR Rules

Browse AMR rules for nuoD

Validation StatusCandidate

Overview

Mechanism: mutations in this gene contribute to tobramycin resistance
Validation Method: genomic sequencing and susceptibility testing
Drug Classes: tobramycin, tobramycin|ciprofloxacin
Organisms: Pseudomonas aeruginosa
Geographic Location: Europe
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R551P	-	-	-	tobramycin\|ciprofloxacin	Reslit	Candidate

Papers2

Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.

PMID 35766499 · 2022

The study identifies various genes and mutations associated with resistance to tobramycin, ceftazidime, and ceftazidime-avibactam in Pseudomonas aeruginosa, highlighting the impact of environmental conditions on the evolution of antibiotic resistance.

Gene Information

Gene Name: nuoD
Allele: nuoD
Encodes: NADH-quinone oxidoreductase subunit C/D
Source Database: Reslit
Mechanism: mutations in this gene contribute to tobramycin resistance
Confers Resistance To: tobramycin
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe
Validation Method: genomic sequencing and susceptibility testing
Sequence Accession: NCBI BioProject PRJNA745005|PRJNA810193

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

R551P

tobramycin|ciprofloxacin

Reslit

Candidate

nuoD

Mutations

Gene Information

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nuoD

Mutations

Gene Information