nuoM

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respiratory complex I subunit

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nuoM

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Validation StatusCandidate

Overview

Mechanism: confers multidrug tolerance
Validation Method: experimental validation through mutation crossing back into ancestral strain and measuring survival
Drug Classes: tobramycin, ciprofloxacin
Organisms: Pseudomonas aeruginosa
Geographic Location: Netherlands|United States|Basel, Switzerland
Papers: 1
Databases: Reslit

Papers1

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.

PMID 33563834 · 2021

The study identifies multiple genes and mutations associated with multidrug tolerance in Pseudomonas aeruginosa, highlighting the role of tolerance in shaping resistance development during chronic infections.

Gene Information

Gene Name: nuoM
Allele: nuoM
Encodes: respiratory complex I subunit
Source Database: Reslit
Mechanism: confers multidrug tolerance
Confers Resistance To: tobramycinciprofloxacin
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Netherlands|United States|Basel, Switzerland
Validation Method: experimental validation through mutation crossing back into ancestral strain and measuring survival
Sequence Accession: CP016955.1|NZ_CP013696.1|CP008870.2|NCBI SRA: Table S4

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nuoM

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nuoM

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