Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
General Bacterial Porin with reduced permeability to beta-lactams
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D18E | - | perturbs the transverse electrostatic field | E. coli | cefotaxime | Reslit | Candidate |
| S271F | - | perturbs the transverse electrostatic field | E. coli | cefotaxime | Reslit | Candidate |
| R124H | - | perturbs the transverse electrostatic field | E. coli | cefotaxime | Reslit | Candidate |
| D192G | - | - | - | carbapenems | Reslit | Candidate |
| N47D | - | - | - | carbapenems | Reslit | Candidate |
| K173T | - | - | - | carbapenems | Reslit | Candidate |
| R195L | - | outer membrane porin C OmpC | Escherichia coli | carbapenemsceftazidime|ceftriaxone|cefepime | ReslitReference Gene Catalog | Candidate |
| G138D | - | - | Escherichia coli | carbapenems | Reslit | Candidate |
| I6T | - | - | E. coli | ceftazidime | Reslit | Candidate |
| I104V | - | - | E. coli | cefepime|cephalothin | Reslit | Candidate |
| I48S | - | - | Enterobacter cloacae | cefoxitin|cefotaxime|cefepime|ertapenem|imipenem|meropenem | Reslit | Candidate |
| A226D | - | increased susceptibility to β-lactam antibiotics | Escherichia coli | ampicillin|piperacillin | Reslit | Candidate |
| Q82Ter | - | outer membrane porin C OmpC | Escherichia coli | carbapenems | Reference Gene Catalog | Candidate |
| Q171Ter | - | outer membrane porin C OmpC | Escherichia coli | carbapenems | Reference Gene Catalog | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| porin_OmpC | Card Database | 1 | - | Escherichia coli | - | - | KY086517.1 | APB87301.1 |
| ompC | Reslit | 7 | ceftazidime, cefepime +10 | Escherichia coli +5 | Europe|wastewater treatment plant, Japan, India | 2022, 2023, 2024, 2025 | PRJNA380388 | - |
A genome-wide scan of wastewater E. coli for genes under positive selection: focusing on mechanisms of antibiotic resistance.
The study identifies ompC and hipA as genes under positive selection that correlate with antibiotic resistance. Non-synonymous mutations in these genes are associated with increased resistance to several antibiotics.
Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains.
The study identified that decreased expression of porin genes ompF, ompC, and phoE contributes to cefmetazole resistance in E. coli, particularly in ESBL-producing strains. The addition of relebactam suppressed resistance acquisition.
The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.
The study identifies multiple mutations in genes such as ampD, deoR, wecA, rcsC, ompC, ompD, and phoE that contribute to antibiotic resistance in Enterobacter hormaechei. These mutations include transposon insertions, deletions, and frameshift variants, leading to resistance against β-lactams, carbapenems, and other antibiotics.
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB.
The study identifies OmpF, OmpC, and LamB as critical outer-membrane porins involved in fosfomycin uptake in E. coli, with their deletion leading to increased resistance to fosfomycin.
Whole genome sequence-based molecular characterization of blood isolates of carbapenem-resistant Enterobacter cloacae complex from ICU patients in Kolkata, India, during 2017-2022: emergence of phylogenetically heterogeneous Enterobacter hormaechei subsp. xiangfangensis.
The study identified several carbapenemase and extended-spectrum beta-lactamase genes, including bla NDM-1, bla NDM-4, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, bla KPC-3, bla CTX-M-15, bla SFO-1, bla ACT, and bla CMH-3, in carbapenem-resistant Enterobacter cloacae complex isolates from Kolkata, India. Novel integrons (In180, In4874, In4887, and In4888) were also discovered.
Upregulation of outer membrane porin gene ompC contributed to enhancement of azithromycin susceptibility in multidrug-resistant Escherichia coli.
The study found that upregulation of the ompC gene enhanced azithromycin susceptibility in multidrug-resistant E. coli, while downregulation of the mph(A) gene reduced azithromycin resistance.
Tripartite Loops Reverse Antibiotic Resistance.
The study introduces tripartite loops consisting of three antibiotics to reverse antibiotic resistance in bacteria. By evolving resistance to a third drug, the study shows that resistance to the initial drugs can be reversed, leading to resensitization. The research highlights the role of specific genes and mutations in mediating resistance and resensitization, including genes involved in electron transport, efflux regulation, and nutrient transport.
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