ompW

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outer membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ompW

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: RNA-seq
Drug Classes: ceftazidime, colistin
Organisms: Klebsiella pneumoniae, Acinetobacter baumannii
Geographic Location: East Asia|Middle East
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N82D	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate

Papers2

Ceftazidime-avibactam based combinations against carbapenemase producing Klebsiella pneumoniae harboring hypervirulence plasmids.

PMID 35950190 · 2022

The study identified several AMR genes, including bla KPC-2, bla OXA-48, and bla NDM-1, in carbapenem-resistant K. pneumoniae isolates. Additionally, the gene ompW was found to be significantly downregulated, potentially affecting antibiotic resistance.

Gene Information

Gene Name: ompW
Allele: ompW
Encodes: outer membrane protein
Source Database: Reslit
Confers Resistance To: ceftazidime
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: East Asia|Middle East
Validation Method: RNA-seq
Sequence Accession: CP039947|CP063280|CP068298|CP076010|MT989343|CP050380|CP072810

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ompW

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ompW

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