ompc_378

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Porin

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to ompc_378

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: Loss of porin function reduces permeability to carbapenems
Validation Method: Whole-genome sequence analysis and antimicrobial susceptibility testing
Drug Classes: ertapenem, meropenem
Organisms: Salmonella enterica serovar Agona, Salmonella enterica serovar Infantis
Geographic Location: Taiwan
Papers: 1
Databases: Reslit

Papers1

Carbapenem resistance in extensively drug-resistant Salmonella enterica serovar Agona and AmpC β-lactamase-producing S. Infantis.

PMID 37787563 · 2023

The study identifies the loss of porins OmpC_378 and OmpD as critical for carbapenem resistance in Salmonella strains producing AmpC or ESBL β-lactamases. It also characterizes several beta-lactamase genes, including bla CTX-M-55, bla TEM-1B, and bla CMY-2, as well as the efflux pump regulatory gene ramAp.

Gene Information

Gene Name: ompc_378
Allele: ompC_378
Encodes: Porin
Source Database: Reslit
Mechanism: Loss of porin function reduces permeability to carbapenems
Confers Resistance To: ertapenemmeropenem
Organisms Tested In: • Salmonella enterica serovar Agona
• Salmonella enterica serovar Infantis
Geographic Location: Taiwan
Validation Method: Whole-genome sequence analysis and antimicrobial susceptibility testing
Sequence Accession: CP090929.1|CP129384.1|CP129386.1|CP093402.1|CP100739.1|CP121066.1|UJA67627.1

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ompc_378

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ompc_378

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