opr86

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outer membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to opr86

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: mutation in opr86 contributes to colistin resistance
Validation Method: genomic sequencing and allelic replacement
Drug Classes: colistin
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P769S	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate

Papers1

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.

PMID 27694971 · 2016

The study identifies several genes and mutations, including pmrB, phoP, phoQ, opr86, and lpxC, that contribute to colistin resistance in Pseudomonas aeruginosa through various mechanisms involving LPS modification and outer membrane structure.

Gene Information

Gene Name: opr86
Allele: opr86
Encodes: outer membrane protein
Source Database: Reslit
Mechanism: mutation in opr86 contributes to colistin resistance
Confers Resistance To: colistin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: genomic sequencing and allelic replacement
Sequence Accession: ERP002380|ERP002381

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opr86

Mutations

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opr86

Mutations

Gene Information