oprC

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RND efflux system outer membrane lipoprotein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to oprC

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Validation StatusCandidate

Overview

Mechanism: overexpression
Validation Method: genomic analysis
Drug Classes: trimethoprim sulfamethoxazole
Organisms: Burkholderia pseudomallei
Geographic Location: Thailand
Papers: 1
Databases: Reslit

Papers1

A Novel Virulent Clinical Isolate of Burkholderia pseudomallei Imported from Thailand Exhibiting Resistance to Trimethoprim-Sulfamethoxazole.

PMID 39437772 · 2025

The study identifies a novel virulent clinical isolate of Burkholderia pseudomallei from Thailand that shows resistance to trimethoprim-sulfamethoxazole. The resistance is attributed to the overexpression of efflux pump genes bpeE, bpeF, and oprC.

Gene Information

Gene Name: oprC
Allele: oprC
Encodes: RND efflux system outer membrane lipoprotein
Source Database: Reslit
Mechanism: overexpression
Confers Resistance To: trimethoprim sulfamethoxazole
Organisms Tested In: • Burkholderia pseudomallei
Geographic Location: Thailand
Validation Method: genomic analysis
Sequence Accession: ASM3014494v1

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oprC

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oprC

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