Browse AMR Genes

Explore antimicrobial resistance genes from the literature

pabC

para-aminobenzoate synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to pabC

Browse AMR rules for pabC

Overview

Drug Classes: phenicols|streptomycin, ethionamide
Organisms: Chromobacterium violaceum, Mycobacterium tuberculosis
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S238L	-	-	Chromobacterium violaceum	phenicols\|streptomycin	Reslit	Candidate
I145M	-	-	Mycobacterium tuberculosis	ethionamide	Reslit	Candidate

Papers2

1

A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD(+)/NADH(+) imbalance.

PMID 28446174 · 2017

A missense mutation (Ser238Leu) in PabC was identified in resistant strains.

Mutation Information

Protein Change: S238L
Organisms: Chromobacterium violaceum
Confers Resistance To: phenicols|streptomycin
Validation Method: whole genome sequencing and Sanger sequencing
Source Database: Reslit

2

Machine learning and phylogenetic analysis allow for predicting antibiotic resistance in M. tuberculosis.

PMID 38124060 · 2023

previously unreported variant

Mutation Information

Protein Change: I145M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ethionamide
Validation Method: phylogenetic analysis and machine learning models
Source Database: Reslit