pafC

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proteasome accessory factor C

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UniProt

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Validation StatusCandidate

Overview

Mechanism: intrinsic resistance
Validation Method: complementation of mutant phenotype
Drug Classes: fluoroquinolones
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics--Fluoroquinolones.

PMID 26139381 · 2015

The study identifies pafC as a novel intrinsic resistance gene in Mycobacterium that contributes to resistance against fluoroquinolones. Deletion of pafC leads to increased sensitivity to fluoroquinolones, and complementation restores the resistant phenotype.

Gene Information

Gene Name: pafC
Allele: pafC
Encodes: proteasome accessory factor C
Source Database: Reslit
Mechanism: intrinsic resistance
Confers Resistance To: fluoroquinolones
Organisms Tested In: • Mycobacterium smegmatis
• Mycobacterium tuberculosis
Validation Method: complementation of mutant phenotype
Sequence Accession: NCBI Gene: MSMEG_3888

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pafC

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pafC

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