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parR

Outer Membrane Porin (Opr);resistance-nodulation-cell division (RND) antibiotic efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to parR

Browse AMR rules for parR

Validation StatusEstablished

Overview

Mechanism: antibiotic efflux;reduced permeability to antibiotic
Drug Classes: colistin, polymyxins, gentamicin|tobramycin, gentamicin, ceftazidime, meropenem, colistin|imipenem
Organisms: Pseudomonas aeruginosa PAO1, Pseudomonas aeruginosa
Papers: 8
Databases: Card Database
Mutations: 8

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
M59I	G177A	two-component response regulator ParR	Pseudomonas aeruginosa	colistincolistin\|imipenem	ReslitReference Gene Catalog	Candidate
E156K	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
A45T	-	-	Pseudomonas aeruginosa	polymyxins	Reslit	Candidate
L153R	-	-	Pseudomonas aeruginosa	polymyxinsgentamicin\|tobramycingentamicin	Reslit	Candidate
S170N	-	-	Pseudomonas aeruginosa	polymyxinsgentamicin\|tobramycin	Reslit	Candidate
V68A	-	-	Pseudomonas aeruginosa	ceftazidime	Reslit	Candidate
L165F	-	-	Pseudomonas aeruginosa	meropenem	Reslit	Candidate
-	C1T	-	Pseudomonas aeruginosa	meropenem	Reslit	Candidate

Papers8

1

Gene Information

Gene Name: parR
Allele: ParR
Encodes: Outer Membrane Porin (Opr);resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux;reduced permeability to antibiotic
Organisms Tested In: • Pseudomonas aeruginosa PAO1
Sequence Accession: AE004091.2
Protein Accession: AAG05188.1
Notes: ARO:3005068

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