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parS

Outer Membrane Porin (Opr);resistance-nodulation-cell division (RND) antibiotic efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to parS

Browse AMR rules for parS

Validation StatusEstablished

Overview

Mechanism: antibiotic efflux;reduced permeability to antibiotic
Drug Classes: colistin, polymyxins, carbapenems, colistin|imipenem
Organisms: Pseudomonas aeruginosa PAO1, Pseudomonas aeruginosa
Papers: 9
Databases: Card Database
Mutations: 12

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L14Q	T41A	sensor histidine kinase ParS	Pseudomonas aeruginosa	colistincarbapenemscolistin\|imipenem	ReslitReference Gene Catalog	Candidate
V101M	-	-	-	colistin	Reslit	Candidate
L137P	-	-	-	colistin	Reslit	Candidate
A138T	-	-	-	colistin	Reslit	Candidate
A168V	-	-	-	colistin	Reslit	Candidate
Q232E	-	-	-	colistin	Reslit	Candidate
G361R	-	sensor histidine kinase ParS	Pseudomonas aeruginosa	colistin	ReslitReference Gene Catalog	Candidate
H398R	-	-	Pseudomonas aeruginosa	polymyxinscolistin	Reslit	Candidate
V216A	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
V295L	-	sensor histidine kinase ParS	Pseudomonas aeruginosa	colistin	Reference Gene Catalog	Candidate
A296P	-	sensor histidine kinase ParS	Pseudomonas aeruginosa	colistin	Reference Gene Catalog	Candidate
V152A	G455C	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate

Papers9

1

Gene Information

Gene Name: parS
Allele: ParS
Encodes: Outer Membrane Porin (Opr);resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux;reduced permeability to antibiotic
Organisms Tested In: • Pseudomonas aeruginosa PAO1
Sequence Accession: AE004091.2
Protein Accession: AAG05187.1
Notes: ARO:3005067

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