Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ATP-binding cassette (ABC) antibiotic efflux pump
Overview
Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.
The study identifies PatA and PatB as ATP-dependent efflux proteins involved in fluoroquinolone resistance in a multidrug-resistant mutant of Streptococcus pneumoniae.
The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB.
The study identifies PatA and PatB as ABC transporters that confer multidrug resistance in Streptococcus pneumoniae. Overexpression of these transporters leads to resistance against fluoroquinolones, dyes, and disinfectants. Inactivation of patA reduces resistance to reserpine and fluoroquinolones, while inactivation of patB primarily affects multidrug resistance.
A novel gene amplification causes upregulation of the PatAB ABC transporter and fluoroquinolone resistance in Streptococcus pneumoniae.
A novel gene amplification leads to overexpression of the PatAB ABC transporter, resulting in fluoroquinolone resistance in Streptococcus pneumoniae.
Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014).
The study identifies several mutations in gyrA, gyrB, parC, and parE genes that contribute to fluoroquinolone resistance in Streptococcus pneumoniae. Additionally, overexpression of patA and patB efflux pump genes is associated with reduced susceptibility to ciprofloxacin.
Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
The study identified multiple AMR genes and mutations in pneumococcal strains from Myanmar, including genes conferring resistance to azithromycin, tetracycline, chloramphenicol, and quinolones, as well as mutations in penicillin-binding proteins and DNA gyrase. These findings highlight the spread of AMR in pneumococcal strains in Myanmar.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Airway "Resistotypes" and Clinical Outcomes in Bronchiectasis.
The study identifies distinct 'resistotypes' in bronchiectasis patients, showing associations with clinical outcomes, geographic origin, and the underlying microbiome. Targeted eradication of P. aeruginosa leads to a shift from a less favorable resistotype to a more favorable one.
Effect of erythromycin residuals in food on the development of resistance in Streptococcus pneumoniae: an in vivo study in Galleria mellonella.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Whole genome sequence and characterisation of Streptococcus suis 3112, isolated from snakeskin gourami, Trichopodus pectoralis.
The study identifies two fluoroquinolone resistance genes, patA and patB, in Streptococcus suis 3112, which confers resistance to norfloxacin but not to other fluoroquinolones.
Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria.
The study identifies and characterizes several efflux pump genes (norA, mepA, bmrA, patA, and patB) in Gram-positive bacteria, demonstrating their role in mediating resistance to fluoroquinolones. A novel diagnostic molecule, 5a4, was developed to quantify efflux activity, showing promise for rapid and accurate detection of efflux-mediated resistance.
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