Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ABC-type efflux pump
Overview
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.
The study identifies the patAB efflux pump as a key determinant of fluoroquinolone, acriflavine, and tetracycline resistance in Streptococcus pneumoniae. A putative upstream sequence (PUS) regulates the expression of patAB, contributing to altered resistance profiles.
Upregulation of the PatAB Transporter Confers Fluoroquinolone Resistance to Streptococcus pseudopneumoniae.
The PatAB transporter was identified as responsible for fluoroquinolone resistance in Streptococcus pseudopneumoniae isolates 5305 and CipR71 through upregulation of the patAB operon, leading to increased efflux of ciprofloxacin, ethidium bromide, and acriflavine.
Role of PatAB Transporter in Efflux of Levofloxacin in Streptococcus pneumoniae.
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