Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 1B
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L41S | - | - | - | penicillin | Reslit | Candidate |
| T491N | - | shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac | Enterococcus faecalis | vancomycin | Reslit | Candidate |
| H510Y | - | - | Streptococcus gordonii | penicillin | Reslit | Candidate |
| A95D | - | - | Streptococcus agalactiae | penicillin|cefotaxime | Reslit | Candidate |
| V80A | - | - | Streptococcus agalactiae | penicillin|cefotaxime | Reslit | Candidate |
| S147A | - | - | Streptococcus agalactiae | penicillin|cefotaxime | Reslit | Candidate |
| S160A | - | - | Streptococcus agalactiae | penicillin|cefotaxime | Reslit | Candidate |
| R526S | - | Streptococcus pneumoniae | penicillin|cefotaxime | Reslit | Candidate | |
| M527L | - | Streptococcus pneumoniae | penicillin|cefotaxime | Reslit | Candidate | |
| N214T | - | Streptococcus pneumoniae | beta lactams | Reslit | Candidate | |
| N531K | - | Streptococcus pneumoniae | penicillin|cefotaxime | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| pbp1B | Reslit | 2 | penicillin, ampicillin +1 | Streptococcus pneumoniae +1 | Netherlands|USA|Thailand | 2017, 2024 | GSE268264 | - |
| pbp1b | Reslit | 3 | beta lactams, penicillin +2 | Enterococcus hirae R17 +3 | China | 1998, 2017, 2025 | CP015516|CP015517 | - |
Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.
The study identifies numerous genes and mutations associated with antibiotic resistance in Streptococcus pneumoniae through genome-wide association studies, highlighting the genetic basis of resistance to penicillin, trimethoprim, cotrimoxazole, erythromycin, and fluoroquinolones.
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.
The study identified multiple antimicrobial resistance genes in Enterococcus hirae R17, including genes conferring resistance to beta-lactam antibiotics, lincosamides, streptogramins, pleuromutilins, polymyxins, tetracyclines, and others. Notably, the strain exhibited resistance to bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline.
Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.
Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.
Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.
The study identified 10 antibiotic resistance genes in the Actinobacillus pleuropneumoniae strain APPFJLYC01, including genes conferring resistance to multiple antibiotic classes such as β-lactams, tetracyclines, aminoglycosides, and macrolides.
Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae.
The study demonstrates the acquisition of five high-Mr penicillin-binding protein (PBPs) variants (PBP2x, PBP2a, PBP2b, PBP1a, and PBP1b) during the transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. These PBPs confer resistance to cefotaxime, oxacillin, and benzylpenicillin.
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