pbp2c

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penicillin-binding protein 2c

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to pbp2c

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: confers resistance to beta-lactam antibiotics by altering the binding site for these drugs
Validation Method: targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Drug Classes: cephalothin
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures.

PMID 38750334 · 2024

The study presents a rapid proteomic method using LC-MS/MS to detect and quantify key antimicrobial resistance effectors in Staphylococcus aureus directly from blood cultures, achieving high agreement rates for PBP2a, PBP2c, APH(3')-III, ANT(4')-I, and AAC(6')-APH(2'').

Gene Information

Gene Name: pbp2c
Allele: PBP2c
Encodes: penicillin-binding protein 2c
Source Database: Reslit
Mechanism: confers resistance to beta-lactam antibiotics by altering the binding site for these drugs
Confers Resistance To: cephalothin
Organisms Tested In: • Staphylococcus aureus
Validation Method: targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Sequence Accession: PASS05841|ENA accession numbers in Supplementary Table 1

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pbp2c

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pbp2c

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