pbpa(2b)

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penicillin-binding protein

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to pbpa(2b)

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: low reactivity with cephalosporins conferring resistance
Validation Method: mutant construction and complementation, MIC assays, PBP acylation experiments
Drug Classes: cephalosporins
Organisms: Enterococcus faecalis, Enterococcus faecium
Papers: 1
Databases: Reslit

Papers1

Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci.

PMID 32041714 · 2020

The study identifies PbpA(2b) and Pbp5(4) as low-reactivity class B penicillin-binding proteins required for cephalosporin resistance in Enterococcus faecalis and Enterococcus faecium. Both proteins exhibit low reactivity with cephalosporins, allowing peptidoglycan cross-linking in their presence.

Gene Information

Gene Name: pbpa(2b)
Allele: pbpA(2b)
Encodes: penicillin-binding protein
Source Database: Reslit
Mechanism: low reactivity with cephalosporins conferring resistance
Confers Resistance To: cephalosporins
Organisms Tested In: • Enterococcus faecalis
• Enterococcus faecium
Validation Method: mutant construction and complementation, MIC assays, PBP acylation experiments

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pbpa(2b)

Gene Information

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pbpa(2b)

Gene Information