The study identifies a mosaic-like structure in the penA gene of Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime, which contributes to resistance against cephalosporins and penicillins.

PenA is a beta-lactamase that contributes to resistance against multiple β-lactam antibiotics. Specific mutations in PenA, including C69Y, P167S, S72F, R7K, and R8A, enhance resistance to certain β-lactams.

The study identifies a novel penA mosaic allele, penA-CI, which confers high-level resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae strain F89. This allele was experimentally validated through transformation and MIC testing.

The study identifies specific mutations in the penA gene of Neisseria gonorrhoeae that affect the interaction between Asp346 and Ser363, influencing penicillin resistance and TPase activity.

The study identifies twelve amino acid positions in the beta-lactamase PenA of Burkholderia thailandensis that can expand its substrate spectrum with single amino acid substitutions, leading to ceftazidime resistance.

The study identifies a P167S mutation in the beta-lactamase gene penA as the cause of ceftazidime resistance in Burkholderia pseudomallei isolates from a patient who developed treatment failure despite ceftazidime therapy.

The study characterizes two substitution mutations in the penA gene within a common SCS element, which contribute to ceftazidime resistance in Burkholderia thailandensis.

A new clinical strain of Neisseria gonorrhoeae (GU140106) with decreased susceptibility to ceftriaxone was identified. The strain exhibited substitutions in the penA gene encoding penicillin-binding protein 2, namely A311V, V316T, and T483S, which are associated with reduced susceptibility to ceftriaxone.

The study identified mutations in the penA and ftsX genes that contribute to ceftriaxone resistance in Neisseria gonorrhoeae. The A501V mutation in penA and the T31P mutation in ftsX were shown to increase the MIC of ceftriaxone.

The paper discusses the mechanisms of antibiotic resistance in Burkholderia species, focusing on β-lactam resistance mediated by penA, penB, and ampC beta-lactamases, as well as efflux pumps like AmrAB-OprA, BpeAB-OprB, and BpeEF-OprC. It also highlights mutations in penA and gyrA that contribute to resistance against β-lactam and fluoroquinolone antibiotics.

The study identifies Saccharomyces cerevisiae IFST 062013 as a potential probiotic with resistance to tetracycline, ampicillin, gentamicin, penicillin, polymyxin B, and nalidixic acid.

The study identifies numerous genes and mutations associated with antibiotic resistance in Streptococcus pneumoniae through genome-wide association studies, highlighting the genetic basis of resistance to penicillin, trimethoprim, cotrimoxazole, erythromycin, and fluoroquinolones.

The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.

A strain of Neisseria gonorrhoeae with reduced susceptibility to ceftriaxone was identified, and the penA X gene was associated with this resistance.

The study identified low levels of azithromycin resistance (0.2%) and no ceftriaxone resistance in Neisseria gonorrhoeae in the Northern Territory of Australia. It also found that ciprofloxacin resistance was significantly lower by PCR than by bacterial culture.

The study identifies a ceftriaxone-resistant Neisseria gonorrhoeae isolate carrying the penA-60 allele, which includes two key mutations (A311V and T483S) that confer ceftriaxone resistance.

The study identified the transmission of antibiotic-resistant Neisseria gonorrhoeae strains between men who have sex with men, highlighting the role of specific genes and mutations in conferring resistance to various antibiotics.

The study identifies the penA gene as significantly associated with penicillin resistance in Neisseria meningitidis through association analysis of core SNPs.

The study identifies upregulation of the RND efflux pumps bpeEF-oprC, amrAB-oprA, and penA duplication as mechanisms of resistance to ceftazidime, trimethoprim/sulfamethoxazole, and doxycycline/meropenem in Burkholderia pseudomallei isolates from cystic fibrosis patients.

The study describes a PCR assay for detecting the penA gene variant associated with ceftriaxone-resistant Neisseria gonorrhoeae FC428 strain, highlighting the importance of monitoring this resistant clone through molecular techniques.

The study identifies the A2543 clone of Neisseria gonorrhoeae, which exhibits resistance to ceftriaxone and high-level resistance to azithromycin, highlighting the emergence of multidrug-resistant strains.

The study identified the presence of the penA gene, which confers resistance to ampicillin, and the catP/D gene, which confers resistance to chloramphenicol, in an antibiotic-resistant Neisseria meningitidis B isolate from a military unit in Vietnam.

The study identified mutations in penA, ponA, mtrR, and porB genes, as well as the presence of bla TEM plasmids, which contribute to benzylpenicillin resistance in Neisseria gonorrhoeae isolates from Russia.

The study identifies several genes and mutations associated with antimicrobial resistance in Neisseria gonorrhoeae, including PenA, mtrR, 23S rRNA, rpsJ, PorB, PonA, GyrA, ParC, and bla. These genetic elements contribute to resistance against various antibiotics such as ceftriaxone, cefixime, azithromycin, tetracycline, ciprofloxacin, and penicillin.

The study characterizes various AMR genes and mutations in Neisseria gonorrhoeae, highlighting the emergence of resistance to multiple antimicrobials over time, including penicillin, fluoroquinolones, macrolides, tetracyclines, and sulfonamides. Key findings include the identification of penB, mtrR, penA, gyrA, parC, folP, rpsJ, tetM, and blaTEM as critical AMR genes, along with mutations in penB, mtrR, gyrA, parC, penA, and ponA that contribute to resistance mechanisms.

The penA allele 60.001 contributes to ceftriaxone and cefixime resistance in Neisseria gonorrhoeae, with strains carrying this allele showing 8- to 16-fold higher MIC values compared to those with penA allele 10.001. Additionally, penA allele 60.001 negatively affects in vivo biological fitness in a mouse vaginal tract model.

The study presents ARDaP, a new tool for comprehensive antimicrobial resistance (AMR) detection in Burkholderia pseudomallei. ARDaP accurately identifies various AMR determinants, including mutations in genes such as penA, bpeT, ptr1, metF, dut, bpsl3085, and amrR, which confer resistance to antibiotics like ceftazidime, meropenem, co-trimoxazole, and doxycycline.

The study identifies mutations in the class A beta-lactamase gene penA and efflux pump regulators bpeR and bpeT that contribute to extensive drug resistance in Burkholderia multivorans, and shows that antibiotic cycling can reverse this resistance.

The study identifies several mutations in genes associated with resistance to ceftriaxone and ciprofloxacin in a Neisseria gonorrhoeae strain from Switzerland, including mutations in penA, porinB, ponA, gyrA, parC, and the 23S rRNA gene.

The study identified multiple AMR genes and mutations in Neisseria gonorrhoeae isolates from Kenya, including mutations in gyrA, parC, penA, ponA1, rpsJ, folP, mtrR, rpoB, pilQ, porB1b, and rplD, which confer resistance to fluoroquinolones, penicillins, cephalosporins, tetracyclines, sulfonamides, rifampicin, and macrolides.

Mutations in the β3–β4 loop of PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae, including F504L, N512Y, and G545S, alter the conformational dynamics of the protein, leading to reduced ceftriaxone binding affinity and resistance.

The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including blaTEM-1, blaTEM-135, tetM, 23S C2611T, rpsJ V57M, mtrR A39T, mtrR G45D, penA mutations, penB mutations, ponA L421P, gyrA mutations, parC mutations, and norM promoter mutations, which contribute to resistance against various antibiotics such as penicillin, tetracycline, azithromycin, ciprofloxacin, ceftriaxone, and cefixime.

The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.

The study identifies the penA 60.001 gene as a key factor in ceftriaxone and penicillin resistance in Neisseria gonorrhoeae strains, alongside the blaTEM-1B gene contributing to penicillin resistance.

The study identified several AMR genes and mutations in N. gonorrhoeae, including bla TEM, tetM, rpsJ_V57M, gyrA_S91F, 16S_rRNA_C1192U, mtrR_G45D, penA_G545S, and penA_mosaic, which are associated with resistance to penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin, cefixime, and ceftriaxone.

The paper discusses the identification of genetic markers associated with resistance to ciprofloxacin, cefixime, and ceftriaxone in Neisseria gonorrhoeae, highlighting the development of molecular assays for resistance-guided therapy.

The paper discusses the development and evaluation of new antimicrobial agents against Neisseria gonorrhoeae, highlighting the importance of monitoring resistance mechanisms such as mutations in GyrA and ParC that confer resistance to fluoroquinolones.

The study reports a ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae isolate (F92) with a novel mosaic penA-237.001 gene, which confers resistance to multiple beta-lactam antibiotics.

The study found that cefiderocol exhibited strong in vitro and in vivo activity against Achromobacter spp. and Burkholderia cepacia complex, including carbapenem-non-susceptible isolates. Whole-genome sequencing identified OXA-114, OXA-364, and PenA beta-lactamases as potential resistance mechanisms in some isolates.

The study identifies mutations in the penA gene of Neisseria meningitidis strains that are associated with reduced susceptibility to penicillin G. Specifically, five amino acid substitutions (F504L, A510V, I515V, G541N, and I566V) in the transpeptidase region of PBP2 were found in strains with decreased penicillin G susceptibility.

The study identifies the penA-60.001 and penA-237.001 alleles as the primary mechanisms of ceftriaxone resistance in Neisseria gonorrhoeae isolates in England. These alleles encode altered penicillin-binding protein 2 (PBP2), leading to reduced susceptibility to ceftriaxone.

Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.

The study identifies penA, mtrR, and porB as key genes involved in β-lactam resistance in Neisseria gonorrhoeae. Mutations in penA, mtrR, and porB contribute to reduced susceptibility to cephalosporins, beta-lactams, macrolides, and tetracyclines.

The study identified penA alleles associated with penicillin resistance, gyrA alleles linked to ciprofloxacin resistance, and rpoB alleles related to rifampicin resistance in Neisseria meningitidis isolates.

The study characterizes the dynamic differences among four Pen beta-lactamases (PenA, PenI, PenL, and PenP) from Burkholderia spp., highlighting their roles in conferring resistance to β-lactam antibiotics through structural and functional analysis.

The study identifies a ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae strain carrying the penA-60.001 allele with the A311V mutation and the 23S rRNA A2059G single-nucleotide polymorphism.

The study identified tetracycline, sulfonamide, and penicillin resistance in Staphylococcus aureus, Enterococcus faecium, and Streptococcus agalactiae isolates from dairy cows in Eritrea.

The study identifies a novel A172T mutation in the penA gene, along with other known penA mutations, as critical contributors to ceftazidime resistance in Burkholderia pseudomallei. It also highlights the role of penA gene duplication and amplification facilitated by palindromic GC-rich repeat sequences.

Taniborbactam effectively inhibits the β-lactamase PenI and its variants C69Y and P167S, reducing the MIC of cefepime in E. coli strains expressing these enzymes.

The study characterizes various mutant forms of the penA gene, which encodes penicillin-binding protein 2 (PBP2), and their impact on resistance to ceftriaxone, cefixime, and penicillin G in Neisseria gonorrhoeae.