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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein
Overview
The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.
The study characterizes the role of the hydrolytic water molecule (WAT_Nu) in the catalytic mechanism of Class A β-lactamase PenP, highlighting the importance of the acyl-enzyme intermediate ES* in coordinating and activating WAT_Nu for nucleophilic attack on the acyl adduct.
Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen beta-lactamases from Burkholderia spp.
The study characterizes the dynamic differences among four Pen beta-lactamases (PenA, PenI, PenL, and PenP) from Burkholderia spp., highlighting their roles in conferring resistance to β-lactam antibiotics through structural and functional analysis.
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