pena1

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class A beta-lactamase

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UniProt

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Validation StatusCandidate

Overview

Validation Method: expression in E. coli and susceptibility testing
Drug Classes: temocillin
Organisms: Burkholderia multivorans
Geographic Location: United States
Papers: 1
Databases: Reslit

Papers1

Resurrecting Old β-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States.

PMID 30718248 · 2019

Temocillin showed potent activity against multidrug-resistant Burkholderia species isolates, particularly against B. multivorans. The study demonstrated that temocillin is not hydrolyzed by endogenous beta-lactamases, making it effective against these resistant strains.

Gene Information

Gene Name: pena1
Allele: penA1
Encodes: class A beta-lactamase
Source Database: Reslit
Confers Resistance To: temocillin
Organisms Tested In: • Burkholderia multivorans
Geographic Location: United States
Validation Method: expression in E. coli and susceptibility testing
Sequence Accession: PRJNA434393

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pena1

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pena1

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